Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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The Biochemist - The gut microbiome in Myalgic Encephalomyelitis

Discussion in 'General ME/CFS News' started by AndyPR, Apr 15, 2017.

  1. AndyPR

    AndyPR RIP PR :'(

    The Biochemist is the bi-monthly publication of The Biochemical Society, and the latest edition is focused on the microbiome. They say "With a circulation of over 7000 readers, largely comprised of students and researchers working in molecular bioscience, The Biochemist provides an ideal opportunity for advertisers to reach a specialist audience."

    Maureen R. Hanson and Ludovic Giloteaux from Cornell University have the following article printed in this edition.

    http://www.biochemist.org/bio/03902/0010/039020010.pdf

    Dr Hanson promoted it on Twitter here
     
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  2. ljimbo423

    ljimbo423 Senior Member

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    Dysbiosis and leaky gut are a huge source of my symptoms. Treating it though, is like trying to run a marathon under water!;)
     
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  3. duncan

    duncan Senior Member

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    Could reduced biodiversity in gut microbiome of pwME be a result of treatments?
     
  4. ljimbo423

    ljimbo423 Senior Member

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    There seem to be a lot of people, both with cfs and researchers, that know the gut is the cause of many symptoms in cfs. Were they seem to part ways is to weather the gut is the primary cause of cfs or secondary to cfs.

    I personally think it's the primary cause and am treating dysbiosis and leaky gut aggressively. I am having very good success, especially in the last 4-6 weeks. Hopefully I will know in a few months (sooner would be better:)), weather it is a the primary cause of my cfs or not.

    This is a quote from Chris Armstrong, the leader of a recent metabolomics study for cfs-

    "Well we all experience a bacteremia when we exercise. The type of bacteria that enter your bloodstream are usually quite controllable by your immune system but if your gut is further compromised they may release more bacteria into your blood or more pathogenic species or your immune system may already be depleted. This is the concept for the chronic sepsis or SIRS and this is what I think may be behind PEM." http://forums.phoenixrising.me/inde...20-2016-metabolomics.47485/page-6#post-791828

    Ian Lipkin and Mady Hornig also seem to think the gut is the core issue- time will tell for sure.
     
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  5. Murph

    Murph :)

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    The melbourne crew (Armstrong et al) are pretty convinced that the gut is a major part of the causation. It makes sense to me - my fatigue symptoms flare if I stray too far from my diet. I've found a probiotic that seems to make a difference at the margin too.
     
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  6. duncan

    duncan Senior Member

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    Nobody knows anything.

    But as a hypothesis, it certainly seems to have merit. I'm just wondering what portion of pwME were tested AFTER some sort of microbial therapies were administered in these gut dysbiosis studies.

    I am a fan of Maureen Hanson, but I think this treatment variable may deserve attention.
     
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  7. Forbin

    Forbin Senior Member

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    An interesting thing about the gut microbiome is that it appears that it can be altered by immune responses to things occurring outside of the gut.
    Speculation:
    This might tie into the apparent "multiple triggers" of ME. What they would all have in common is that they stimulate the immune system to alter the microbiome, leading to "leaky gut." The subsequent immune response to "leaky gut" itself might then turn this into a vicious cycle, never allowing the microbiome to return to normal.
     
  8. trishrhymes

    trishrhymes Save PR. Sack the President of the Board.

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    Can you point me in the direction for information on how to do this? (probably best not to derail this thread with individual stories of treatment).
     
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  9. echobravo

    echobravo Keep searching, the answer is out there

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    @ljimbo423, I would be curious to know how you treat your dysbiosis and leaky gut..

    Aboit a year ago the CSA stool test showed a compromised gut flora (lacking good species, overgrowth of some pathogene species, yeast) I have improved going low carb & paleo, eliminating sugars & starches and also supplementing with tryptophan, zinc, l-glutamine, omega-3 etc. For leaky gut I also use broth, fermented cabbage, kefir, probiotics, beet kvass etc. The result is less pain and headaches, but energy is still low.
     
  10. anciendaze

    anciendaze Senior Member

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    Has anyone posted a correction about the terms ME and CFS? CFS was the term introduced in 1988, over the objections of some very competent doctors who had seen the problem in the 1950s. Benign myalgic encephalomyelitis was introduced in 1956. The benign adjective was dropped by Ramsey after it became clear the disease could be completely disabling and life-long. The article mixes this up.
     
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  11. ljimbo423

    ljimbo423 Senior Member

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    @trishrhymes and @echobravo


    About 90% of my treatment plan came from here, under the treatment tab. Feel free to PM me if you want more details.:)
     
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