Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndrome
http://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
Discuss the article on the Forums.

The Big Vitamin D Mistake. 2017 Papadimitriou DT. J Prev Med Public Health.

Discussion in 'Other Health News and Research' started by *GG*, Dec 7, 2017.

  1. *GG*

    *GG* Moderator

    Messages:
    6,213
    Likes:
    4,849
    Concord, NH
    Abstract
    Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical.

    A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L.

    Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels.

    Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses.

    This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.

    https://www.ncbi.nlm.nih.gov/m/pubmed/28768407/
     
    sb4, CFS_for_19_years, ahmo and 11 others like this.
  2. rodgergrummidge

    rodgergrummidge Senior Member

    Messages:
    115
    Likes:
    236
    Yes @*GG* , Unfortunately, diet and sunshine are not sufficient to maintain adequate levels of vitamin D in many people. It is estimated that a 1 billion people worldwide have a Vitamin D deficiency; the significant health consequences have been described as a ‘pandemic’.

    While Vit D is widely known for its important roles in regulating calcium homeostasis and bone health, what is often overlooked is that Vit D plays critical roles in the immune system to help fight infections and to reduce the liklihood of excessive immune activation leading to autoimmune diseases.

    Vitamin D deficiency is associated with an increased likelihood of IBD, RA, Type I diabetes, SLE, osteoarthritis and MS. In addition, those with low vit D are more prone to reactivation of latent virus leading to chronic activation of T-/B-lymphocytes and excessive cytokine production. All these immune functions of Vit D are likely to be critical in CFS.

    While the precise blood levels of 25-hydroxyvitamin D necessary for bone and immune health are still hotly debated, many are now recommending levels over 75nmol/l, with some even recommending levels >100nmol/l.

    Supplementation of Vitamin D3 that leads to prolonged serum levels of 25-hydroxyvitamin D greater than 370nmol/l (or 150ng/ml) is associated with significant toxicities.

    Rodger
     
  3. pattismith

    pattismith Senior Member

    Messages:
    1,065
    Likes:
    1,597
    be carefull, my laboratory recommends that supplementation with biotine must be stopped minimum 8 days prior the dosage of vitaminD because of interferences.
     
    Last edited: Dec 8, 2017
    Isaiah 58:11 and Gondwanaland like this.
  4. HowToEscape?

    HowToEscape? Senior Member

    Messages:
    521
    Likes:
    692
    Finland is rather cold and lacking in sun. Someone living in Southern California would be ill served by eating that amount of vitamin D.
     
    Skycloud likes this.
  5. notmyself

    notmyself Senior Member

    Messages:
    343
    Likes:
    470
    Vit D is also important for muscle health from what i know..is preatty much the only blood test that come back bad for me..i was deficient at 16 ng/ml..i take for like one month 2000 UI a day and stopped and never checked again, i wonder if i ever fixed the deficiency..i didin t pay much attention to it, cause all teh doctors i've seen weren t much concern about it, they say it's a deficiency but should not cause much problems...maybe they were wrong
     
    *GG* and pattismith like this.
  6. CFSTheBear

    CFSTheBear Senior Member

    Messages:
    142
    Likes:
    615
    No way of telling other than to get re-tested.

    Vitamin D deficiency was remarkably easy to correct in my experience earlier this year. Went from deficient to 97nmol after two months of supplementing 2,000 IU a day and lying down in the garden outside.

    Unfortunately, had 0 effect on symptoms, and I'm actually worse now than when I got diagnosed (not saying it's anything to do with the vit d).
     
    flitza, JeanneD, Skycloud and 2 others like this.
  7. justy

    justy Donate Advocate Demonstrate

    Messages:
    5,353
    Likes:
    12,224
    U.K
    Unfortuantely vitamin D causes me to have severe joint pain and flu like feelings. I do have Cpn and have heard thats possible. I am deficient and need to try and add some more in again. I live in Wales - low levels of sunlight and i dont go out the house often at all.
     
    JeanneD, anni66 and Skycloud like this.
  8. keenly

    keenly Senior Member

    Messages:
    633
    Likes:
    671
    UK
    Vitamin D causes increased Calcium uptake. We already have an issue with high intracellular calcium.

    You are likely surround by nnEMF, this causes calcium efflux.
     
    sb4, MissMarple, ahmo and 1 other person like this.
  9. kangaSue

    kangaSue Senior Member

    Messages:
    878
    Likes:
    970
    Brisbane, Australia
    They're not cheap but a Sperti lamp could be what you need for getting Vit D.
     
    justy likes this.
  10. Learner1

    Learner1 Professional Patient

    Messages:
    1,586
    Likes:
    2,805
    Pacific Northwest
    @justy Do you by chance have any issues with wool? My friend was having problems taking vitamin D, but we learned that vitamin D frequently comes from lanolin from sheep wool. She's allergic to wool, but was able to find an alternative to raise her vitamin D level.
     
  11. JeanneD

    JeanneD Senior Member

    Messages:
    130
    Likes:
    350
    I believe this is generally the case, but it is most definitely not for some of us. I could not get into range for years, despite the best efforts of my doctors and plenty of sun exposure. The same was true for my daughter.

    During that period, the only time I got in-range was when a Ca supplement I was taking was accidently made with 10,000 times the listed amount of Vit D. I took it for months. When the recall notice came, I had my Vit D levels tested, as advised. I was actually just barely over-range. I felt great. Obviously no one thought it wise for me to continue to take anything close to that amount of vit D, even though it was the only way I could stay in range.

    I went back to taking the highest vit D dose my doc felt was safe and my vit D levels plummeted rapidly back below range.

    Ours are not the only stories I've heard of pwme who cannot stay in-range for vit D despite sun exposure, healthy eating, and the highest recommended supplementation. My ME specialist said it's not unusual for ME patients to have difficulty keeping vit D levels in range and to need the highest supplementation to achieve it. We just happened to be extreme cases of that phenomenon.

    As with everything ME, there are also plenty of pwme with no difficulty maintaining vit D levels. So many differences among us and so many similarities. I hope I live long enough to hear the explanation for that.
     
    Learner1 likes this.
  12. kangaSue

    kangaSue Senior Member

    Messages:
    878
    Likes:
    970
    Brisbane, Australia
    Vitamin D can be had as an intramuscular injection of cholecalciferol at up to 600,000 i.u. at a time. Being lipid soluble, the absorption can be poor if you are lacking fat in your diet or short of body fat. Any oral supplement is best taken with a fatty meal for maximum uptake too.
     
  13. *GG*

    *GG* Moderator

    Messages:
    6,213
    Likes:
    4,849
    Concord, NH
    Just because you live in CA, does not mean you are out lots getting lots of sun!

    GG
     
    flitza and HowToEscape? like this.

See more popular forum discussions.

Share This Page