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TGF-Beta 1 results?

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by 3CFIDS@ourhouse, Nov 17, 2010.

  1. 3CFIDS@ourhouse

    3CFIDS@ourhouse still me

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    Southeast US
    Does anyone know what Transforming Growth Factor (or TGF-Beta1) results mean? What is normal? What is typical for us? Thanks!
  2. Tony

    Tony Still working on it all..

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    Melbourne, Australia
    REDlabs have this test listed under Immune Dysfunction. It's grouped as Cytokines: Cytokine RNA, inflammatory IL-6, IL-8, IL-10, TNF, TGF-1, MIP-1 mRNA levels.

    The reference range they use is 0.00 - 30.00. I understand it to be an indicator of Th17 which can promote inflammation and blood brain barrier disruption...
  3. lono

    lono

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    My understanding is that if your TGF-beta-1 is elevated if it's greater than 2380 pg/mL. I'm not an expert, but if it's elevated that's characteristic of many inflammatory and autoimmune conditions.

    If you read other postings on this board you'll see that CFS/ME folks who have elevated TGF-Beta-1 also very often have elevated C4a, low melanocyte stimulating hormone (MSH) and low vasoactive intestinal peptide (VIP). Dr. Ritchie Shoemaker has done the most work in this area; his theory is that people with these abnormalities are stuck in a chronic inflammatory response syndrome (CIRS) state.

    Not everyone with CFS/ME has these abnormal biomarkers, but many of us do.

    As with most everything having to do with CFS/ME, there's nothing currently in the medical literature about this.
  4. JanisB

    JanisB Senior Member

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    Central Ohio
    Hi Lono,
    This is something I'm VERY curious about. I had the panel of tests Shoemaker recommends and definitely have CIRS (for more details, see my blogpost IS ME/CFS CIRS http://cfsmethylation.blogspot.com/2011/04/is-me-cfs-cirs.html) I do not have elevated TGF-beta 1, however.

    What evidence do you have that 'not everyone with CFS/ME has these abnormal biomarkers"? Do you know people with CFS/ME who don't meet the criteria for CIRS?
  5. ttt

    ttt

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    Santa Monica, CA
    I just wanted to bump this thread. I just got my TGF-Beta1 results back, and they're really high. Anyone know what this means?
  6. Overstressed

    Overstressed Senior Member

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    Belgium
    Hi ttt,

    I have an aneurysm of my aorta, and it looks like TGF-Beta is involved. I don't know the details, though, whether it's typical high, or low or disrupted. Perhaps it's a good moment to have your heart and aorta checked. Genetics do also play a role, most likely.

    Best regards,
    OS.
  7. ttt

    ttt

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    Santa Monica, CA
    Thanx, OS. I don't think it's a heart/aorta issue for me -- I think it means something else. But I appreciate the feedback, cause you just never know.

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