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New Exercise Study Brings Both Illumination and Questions
Simon McGrath looks at new objective evidence of abnormal response to exercise in ME/CFS patients, and the questions that researchers are still trying to answer ...
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  1. Cort

    Cort Phoenix Rising Founder

    Messages:
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    Raleigh, NC
    Diurnal Cortisol levels, 24hr. Urine free Cortisol
    Hormones including:
    Free testosterone, B12 & folate levels
    DHEA sulphate
    5-HIAA screen
    abdominal ultrasound
    stool for Ova & parasites
    NK cell activity
    flow cytometry for lymphocyte activity
    Western Blot for Lyme
    Bartonella
    Ehrlichiosis
    Babesia
    Rickettsia
    chest X-ray
    TB skin test
    HIV
    37-kDa 2-5A RNase l Immunoassay
    For Neurological tests:
    X-ray &/or MRI Brain & Spinal Cord
    Tilt-Table*
    Sleep Study
    qEEG, SPECT & Pet Scan
    24 hr. Holter Monitoring
    Romberg's Test (Romberg maneuver)
    uric acid
    Immune:
    Muscle Wasting.
    Fungus infection of ALL toenails = Lyme,Immune compromised if in youth/young.
    Molds in serum: (IgG: Candida Albicans, Aspergillus nige, Penicillium chrysogenum, Cladosporium herbarum, Alternaria alternata, Aspergillus fumigatus).
    Inflammatory cells in urine (in combination of flank pain/cloudy urine yet absence of UTI).
    Apoptosis of neutrophils.
    Low Saliva Secretory IgG.
    CD4/C8 Ratio.
    Free T3 and free T4
    Increase Cytotoxicity of NK Cells.
    TH17 Activation.
    NF-kB activation.
    CD14, C4A changes.
    B-cell immunodeficiency depletion of CD19+IgM+ mature B-lymphocytes.
    Elevated Monocytes on a consistent basis (indicative of infection).
    Increased L-forms (small-colony variants) of coagulase negative staphylococci.
    Consistent or Permanent Red throat at trips to doctors office points to obvious repeat/chronic infection OR virus.
    Increased serum concentrations of IgM and IgA to lipopolysaccharide (LPS) of gram-negative enterobacteria.
    ESR.
    Presence of Auto Antibodies.
    Leucocyte Elastase activity.
    Protein kinase R activity.

    Neurological:
    Neurogenic/Saggy Bladder leading to overfill.
    Slow voiding of bladder.
    Lumbar Puncture: Cytokines in CSF and low GM-CSF. Very raised Ventricular CSF Lactate.
    Lowered tryptophan with increased Trycat.
    Sluggish Pupil Response to changes in light. (Not pen torch to the eye). Lights Dim, Lights On.
    One Pupil larger than the other.
    QEEG to look for seizure spikes and slow brain waves.
    Reflexes: Look for 'Hyper-Reflexia'.
    Vestibular dysfunction especially after exercise (changes in gait).
    Neurotransmitter: Decreased Homovallinate
    Raised Serotonin (Especially in Men).
    Abnormal Lowered IQ on NeuroPsychometric Testing.

    Neuro Imaging:
    Shrinkage of Grey Brain Matter.
    Changes in Choline which indicates brain damage: MRS Scan.
    fMRI (Functional MRI): Changes in mental fatigue/blood oxygen levels during cognitive tasks.

    Endocrine/General:
    Low Niacin.
    Low Functional SODase Inhibition.
    Low Co Enzyme Q10.
    Low Red Cell GSH-PX .
    Low Amino Acids.
    Low Aldosterone (May explain passing copious clear urine, not explained by Diabetes Insipidus Diagnosis or excess water intake).
    CT or adrenal glad to check for atrophy. (May be abnormally small).
    5Hr Glucose Tolerance Test with Insulin and Cortisol Levels (Should show poor Insulin curve).
    Short Synacthen Test (Should show classic blunted response).
    Buspirone Challenge Test (5-HIAA abnormal response).
    Abnormal Post Praindial Insulin (Food).
    Raised levels of Pesticides in Serum and especially fats. (Pesticide Fat Biopsy).
    Low Esssential Fatty Acids (EFA).
    Citric Acid Cycle: Decreased.
    Low Glutathione-S-transferase.
    Low Calcium/Potassium/Inorganic Phosphate.
    Vasculitis.
    Low Iodine.
    Quinolinic acid (Neuro Toxin).

    Cardio/Autonomic

    Raised HS-CRP (Must be High Sensitivity).
    Raised Homocysteine (plasma).
    Raised Plasma Isoprostanes.
    Raised 'bad' Cholesterol.

    Observation of Orthostatic Intolerance narrowing of blood presssure 'gap' from supine to erect: E.g. 123/80 laying flat, (Correct 40 gap) 130/120 standing up. (Abnormal 10 gap with Diastolic hypertension!)

    Abnormal mottling of hands in erect position. (local vasocontriction due to sympathetic nervous drive).
    Abnormal blood pressure overshoot (needs specialist equipment during autonomic testing).

    Heart Rate Variablity Test showing sympathetic nervous system in prodimant state supine and absence of parasympathetic activity resting. Severe Sympathetic activity standing.

    24/hr Holter cardiac monitor: May show bradycardia in sleep, shortened QT interval, Abnormal exertional tachycardia in absence of SVT OR runs of SVT if suffering from previously unexplained abrupt onset tachycardia.

    Metabolic:
    Very Raised Oxidative Stress/Free Radical assays (iNOS and NOS).
    Low core temperature, especially after hard exercise.(Reverse of normal).
    Raised Nitrite in Urine after exercise.
    Decreased VO2 Max and/or on 2nd following day of repeat testing (unique to ME/CFS).
    Increased D-Glucaric Acid.
    Lymphocyte Translocator Protein Studies for ATP: Poor TLP function for energy
    Poor Lymphocyte ATP.
    Poor Lymphocyte ADP to ATP.
    DNA Adducts Toxins stuck onto DNA (Pre Cancerous).
    Raised Cell Free DNA (DNA leaking into blood due to damage) causing tissue damage.
    Unexplained and episodic amorphous debris in urine indicative of 'sloughing' from kidneys.

    Haematological:
    Abnormal amout of cupped Red Blood Cells (Changes in Red Blood Cell Morphology).

    Medical Procedures:
    Sigmoidoscopy: May show weak rectal muscles, explaining continance problems, or 'seapage' of rectal mucus into underwear.
    Ultrasound of Thyroid Gland: May be enllarged due to poor thymus function and inflammation in absense of hypothyroid.
    Testicular Examination in males: May be unusually extremely tender.
    DEXA Bone Density Scan: May show early onset Osteoporosis.

    MRI = Magnetic Resonance Imagining

    SPECT = Single Photon Emission Computed Tomography

    BEAM = Brain Electrical Activity Mapping

    QEEG = Quantitative Electro-Encephalo-Gram

    VIP Dx

    CMCP Complete Chronic Fatigue [CFS] Diagnostic Panel (RNAP, RNAA, ELAS, NKCP, NOAS)

    MCP1 Mini Chronic Fatigue (CFS) Diagnostic Panel (RNAP, RNAA, ELAS, NOAS)

    RNAL RNase-L Anti-viral Pathway (RNAP, RNAA)

    IM01 Intestinal Dysfunction Immunobilan Test (IgA, IgM)

    HTLV T-cell Lymphotrophic Virus Profile (HTLV I, HTLV II)

    INSP Infection Screen Panel- Qualitative (Mycoplasma Fermentans, Mycoplasma Hominis, Mycoplasma Pneumoniae, Mycoplasma Avium Paratuberculosis, Chlamydia Pneumoniae, Toxoplasma gondii)

    HHVP Herpes Infection Panel (EBV, CMV, HHV6 [with A & B determination}, HHV7, HHV8)

    MYCP Mycoplasma+ Panel - Qualitative
    (Mycoplasma Fermentans, Mycoplasma Hominis, Mycoplasma

    Pneumoniae, Mycoplasma Avium
    Paratuberculosis)

    CYT1 Inflammation Cytokine Profile
    (IL1β, IL2, IL4, IL6, IL8, IL10, IL12p70, IFNγ, TNFα,)

    INFP Inflammation Panel (C-reactive Protein, Elastase, Nitric Oxide Synthase, Rheumatoid Factor)

    LYEA CD4/CD8 Lymphocyte Enumeration Assay (CD3, CD4-CD8 ratio, CD19 Absolute)

    NKCP Natural Killer Cell Enumeration & Functional Assay (LU 30) Panel

    HLP1 Heavy Metals Sensitivity Test - HELPTM Test (Arsenic, Copper, Lead, Platinum, Thiomersal, Palladium, Mercury, Gold, Silver, Aluminum, Beryllium, Nickel, Organic Mercury, Tin)

    HLP2 Heavy Metals Sensitivity Test - HELPTM Test
    (Chromium 3, Selium, Uranium, Cadmium, Chromium 6, Silicon, Cobalt, Manganese, Titanium)

    Blood Volume Daxor BVA-100 an FDA approved system which indicates a CFS use on their website? www.daxor.com/indications.asp
  2. Cort

    Cort Phoenix Rising Founder

    Messages:
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    431
    Raleigh, NC
    Anyone want to clean these up? Categorize them?
  3. JT1024

    JT1024 Senior Member

    Messages:
    534
    Likes:
    286
    Massachusetts
  4. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    431
    Raleigh, NC
    OK pop it in there.....Do I discern a reluctance to throw items onto the page?. :)
  5. taniaaust1

    taniaaust1 Senior Member

    Messages:
    7,726
    Likes:
    4,570
    Sth Australia
    i just fixed the spelling of Romberg (it was written as Rhomberg) .. and added Rickettsia to the list.

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