Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Tests of blood-borne DNA pinpoint tissue damage

Discussion in 'Other Health News and Research' started by Marco, Mar 16, 2016.

  1. Marco

    Marco Grrrrrrr!

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    When diseases cause tissue damage DNA fragments are released into the bloodstream. When a disease primarily causes damage to a specific organ or cell (pancreatic cancer, pancreatic beta cells in diabetes, brain oligodendrocytes in MS or glial/neuronal death in traumatic brain injury) it may be possible to identify the 'unique signature' from a simple blood test.

    It would be nice to apply this technology to ME/CFS although I suspect you would need to have a fair idea where where you should be looking :

    http://www.sciencemag.org/news/2016/03/tests-blood-borne-dna-pinpoint-tissue-damage
     
  2. justy

    justy Senior Member

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    When Myhill tested me I had a VERY high cell free DNA - would this be related in any way?
     
  3. Marco

    Marco Grrrrrrr!

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    Hard to know without knowing what test she uses?
     
  4. justy

    justy Senior Member

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    Its part of the mito profile done through acumen. Just says 'Cell free DNA' its a blood test if that helps...
     
  5. Marco

    Marco Grrrrrrr!

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    From what I can see, unless you're looking for something specific, it's just a non-specific indication and normal values can vary markedly.
     
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  6. anciendaze

    anciendaze Senior Member

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    If you don't distinguish nuclear and mitochondrial DNA what you will get from a measurement of cell-free DNA could be almost entirely mitochondrial DNA. Mitochondria outnumber nuclei by factors of thousands. This seems a reasonable measure for a mitochondrial panel, but it won't identify specific tissues because every living human cell has mitochondria.

    I'm also curious about the way they deal with viral DNA. Recall that at least 8% of human genomes are viral DNA.
     
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  7. Justin30

    Justin30 Senior Member

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    Maybe they could try the test on early diagnosed ME. See where the cells are sheading from then possibly look for early intervention strategies.

    Just a thought. I think organ damage in ME comes about much later at least from what I have read.
     

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