There's a problem that faces those of us who want to tap into the huge variety of medical theory and supplements available... there are so many things to try! I have to give each thing I try, whether new itself, a new dosage, or a new combination of previously tested agents, a nice long period to settle and adjust. Ideally two months. But if I waited two months to make a change I would only try six things a year, and we know that we'd NEVER GET TO HEALTH that way. One reason I suggest "two months" as a waiting period is that I have Bipolar II and even with medications my moods and energy levels are all over the place. I have no ability to take a new supplement and have any kind of fine discernment about what it did. Only if it has a huge effect can I tell. Recently a few supplements did have huge effects on me, like adb12 (adenosylcobolamim) and DHEA. Also Lithium. After some time of taking those regularly, I started to identify downsides, problems that seem to crop up when taking too much of them over a period of time. That leads to a new rule I have for myself: if a supplement has a big effect immediately, take that supplement only a very low level for sustained use. This is basically the idea that a huge effect probably means it's tapping into some underused biochemical system which is missing some of the cofactors. I don't want to get that system going like mad. In a while, After adding other cofactors and miscellaneous things, I can try a small increase in the sustained level of that medication. Another idea: I could introduce new supplements in groups and look first for major negative reactions. Try to construct a group from mostly low-risk supplements that you don't think you are going to react to, that hardly anyone reacts to. So a major negative reaction points to you high-risk supplements. Do an experiment over the next few days and nail down which supplement is the problem one. Or if you get a big positive reaction, again experiment. But in many cases you'll have mild reactions, probably mild benefit. Then just keep the whole group in your daily regimen. This would be , for instance, for types of supplements that are low-risk with nearly a perfect record of evidence suggesting they are helpful, like maybe CoQ10 for the Krebs cycle. Any other ideas for how to manage the experimentation with large numbers of options?