thank u so much, I am diagnosed with eds classical, chiari 1, and pots/;hyper adernergic/oi, but not sure if I do have ME or the MCAS, could those be giving me my issues/symptoms? and not caused by the eds, chiari and pots/oi? My blood test look normal execpt for the urin methyl above and the norepineprine , and my b12 was 1386. Anyone have a high b12? but I have symptoms of b12 defiency, so I do NOT understand. My doctor has not said anything more about the high b12 but I am worried from what I googled said bad things about high b12. Please if any of you had high b12 tell me what helped you get back to normal level? and coudl the MCAS OR ME be the cause of it?