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Telomere/telomerase dynamics: effect of chronic infection and stress

Discussion in 'Other Health News and Research' started by guest, Feb 24, 2011.

  1. guest

    guest Guest

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    Does anyone have full access to this paper?

    http://www.ncbi.nlm.nih.gov/pubmed?term=20833238

    Abstract
    Aging of the immune system is a major factor responsible for the increased severity of infections, reduced responses to vaccines, and higher cancer incidence in the elderly.
    Indeed, high proportions of senescent CD8 (cytotoxic) T lymphocytess are associated with latent cytomegalovirus (CMV) infection in the elderly, and are part of a cluster of immune biomarkers that are associated with early mortality. Similar cells accumulate at younger ages in persons chronically infected with HIV-1. In addition to persistent viral infection, psychological stress as well as oxidative stress can also contribute to the generation of senescent dysfunctional T lymphocytes. Strategies such as cell culture manipulation of replicative senescence, as well as lifestyle and stress reduction techniques are discussed in terms of possible approaches to enhance immune function in older persons. This review highlights the importance of using humans in studies on immunosenescence and telomere/telomerase dynamics, since model organisms employed in other facets of aging research are not subject to the particular factors that cause the striking age-related reconfiguration of the human immune system.

    Copyright 2010 Elsevier Inc. All rights reserved.
    PMID: 20833238 [PubMed - in process]

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