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Telegraph newspaper article on potential Autism test

Discussion in 'Other Health News and Research' started by V99, Jun 3, 2010.

  1. V99

    V99 *****

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    http://www.telegraph.co.uk/health/healthnews/7801077/Autism-test-could-make-the-condition-preventable.html

  2. julius

    julius Watchoo lookin' at?

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    Can anybody find the actual study? I really want to know more about this one. Especially which test and where can I get it done.
  3. V99

    V99 *****

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  4. V99

    V99 *****

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    On their websitte they have this.
    Here is a link to that journal http://pubs.acs.org/journal/jprobs?cookieSet=1
  5. V99

    V99 *****

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    This is the content of their web page.

  6. julius

    julius Watchoo lookin' at?

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    Awesome!

    Thanx :D
  7. Rosemary

    Rosemary Senior Member

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    Thank you for this information V99

    This research reminds me of Paul Shattock's research .....Sir Paul has spent the past decade analysing thousands of urine
    samples from people with autism.
    [ Paul Shattock, scientific consultant to the Espa Autism Research Unit in Sunderland ]


    He believes that the prime suspect for the steady increase in autism cases in the UK is exposure to organophosphates contained in modern
    pesticides.

    also interesting to note that the Sunderland research unit recently acquired a sophisticated 'mass spectrometry machine' which can identify minute chemical traces in bodily fluids.

    In the Telegraph study above they used a 'Nuclear Magnetic Resonance Spectroscopy '
    Does anyone know more about the type of machines that they are using for this testing ?



    Quote from Telegraph research above

    " The researchers reached their conclusions by using a ' Nuclear Magnetic Resonance Spectroscopy ' which is able to analyse the make-up of chemicals.

    They used the machine on samples three groups of children aged between three and nine – 39 children who had previously been diagnosed with autism, 28 non-autistic siblings of children with autism, and 34 children who did not have autism and did not have an autistic sibling.

    They found that each of the three groups had a distinct chemical fingerprint. Non-autistic children with autistic siblings had a different chemical fingerprint than those without any autistic siblings, and autistic children had a different chemical fingerprint than the other two groups. "
  8. Rosemary

    Rosemary Senior Member

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    Is this then linked to the CD26/DPP1V impairment and the subsequent inability to break down neuropeptides ?

    As Athene kindly explained on the thread below it is actually Paul Shattock that is also doing the gluteomorphin and caseomorphin research and testing at Sunderland

    Klimas London presentation, CD26/DPPIV impaired in CFS - retroviral involvement?
    http://www.forums.aboutmecfs.org/sh...-impaired-in-CFS-retroviral-involvement/page3

    Quote from Athene

    In case anyone is interested, this explains the gluteomorphin and caseomorphin research project done at the University of Sunderland

    http://www.espa-research.org.uk//urine.html

    They've been analysing urine samples for years, have done thousands, and have found consistent results. The link explains some of the requirements for reliable results in detecting these unstable organic compounds. The wee needs to be very fresh and stored with a preservative for a max of 24 hours. This may be where the other research project failed.

    If you live in the UK you can get your wee tested by them for these gluten and dairy derived compounds - it's not expensive. Follow link for details.

    For anyone interested in trying GFCF, there is a lot of info on this site.
  9. Rosemary

    Rosemary Senior Member

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    Hi Julius....BTW you are so CUTE !

    If you are interested here is some information about the ESPA Research testing [UK] by Paul Shattock
    ESPA Research (Autism Research Unit)

    Our research
    Our primary research interests include:

    1.The potential use and effectiveness of gluten-(and/or casein-) free diets for the alleviation of some of the symptoms of autism [ClinicalTrials.gov ID: NCT00614198] (see 'ScanBrit trial').

    2. Analysis of the urine of people with autism and related conditions to seek chemical entities that could provide insight into any underlying metabolic abnormalities and/or predict best or non-responders to dietary intervention.

    3.The application of a health informatics approach to autism and related conditions.

    Details of journal papers and books published by members of ESPA Research can be found in 'Publications'. Details of our primary research goals can be downloaded by clicking below.

    http://www.espa-research.org.uk//research.html
  10. julius

    julius Watchoo lookin' at?

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    Thanks Rosemary,

    I just looked at the site and emailed them a question. I am not sure if their tests are available to ppl in Canada.
  11. natasa778

    natasa778 Senior Member

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    just reading the abstract, the newspaper article was off the mark (no kidding :) - the study was not about early detection, and results do NOT indicate that these markers were present from an early age....


    but they are def there now!

    Novel findings associated with alterations in nicotinic acid metabolism within autistic individuals showing increased urinary excretion of N-methyl-2-pyridone-5-carboxamide, N-methyl nicotinic acid, and N-methyl nicotinamide indicate a perturbation in the tryptophan−nicotinic acid metabolic pathway. Multivariate statistical analysis indicated urinary patterns of the free amino acids, glutamate and taurine were significantly different between groups with the autistic children showing higher levels of urinary taurine and a lower level of urinary glutamate, indicating perturbation in sulfur and amino acid metabolism in these children. Additionally, metabolic phenotype (metabotype) differences were observed between autistic and control children, which were associated with perturbations in the relative patterns of urinary mammalian-microbial cometabolites including dimethylamine, hippurate, and phenyacetylglutamine. These biochemical changes are consistent with some of the known abnormalities of gut microbiota found in autistic individuals and the associated gastrointestinal dysfunction and may be of value in monitoring the success of therapeutic interventions.

    http://pubs.acs.org/doi/full/10.1021/pr901188e?prevSearch=autism&searchHistoryKey=


    btw ryptophan−nicotinic acid metabolic pathway is linked to IDO/interferron pathway, ie infection/inflammation!
  12. aquariusgirl

    aquariusgirl Senior Member

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    rich
    if you're reading this... isn't it odd that urinary glutamate would be low ??
    I thought amy was finding the reverse..unless these kids were already on a gluten free diet.
    I think I'm missing sthg here....
  13. richvank

    richvank Senior Member

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    Hi, Aquarius.

    That surprised me, too. I think the elevated taurine is consistent with Dr. Amy's findings, and she would certainly agree with the perturbation of sulfur metabolism and amino acids metabolism, but yes, the low glutamate is a little puzzling.

    Rich
  14. natasa778

    natasa778 Senior Member

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    It is actually quite usual for some of markers to be present in different levels in blood versus CNS, ie for some neurotransmitter molecules low blood levels would automatically indicate HIGH CNS LEVELS. And the other way round.

    I don't know if glutamate is on of those :Retro redface:, but it would make sense...
  15. JillBohr

    JillBohr Senior Member

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    I think this is great that they may have a potential (and cheap) biomarker for autism. If I knew then what I knew now, I would have had my kids on probiotics (and other treatments) much much earlier. I would love to compare the urine results with ME/CFS patients. I am also thrilled that researchers are taking a serious look at the gut issue. This is a major problem for my children. I can eat almost anything (I swear I have the stomach of a stray dog) and I wonder if that is why I am not sick.
  16. Rosemary

    Rosemary Senior Member

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    Hi Julius....I hope that you received some feedback and answers to your questions
  17. julius

    julius Watchoo lookin' at?

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    Yep, I can do it from Canada, anywhere in the world in fact. It's 60 pounds (around $100 I think). I have to learn a bit more to see if it's worth it for me.
  18. Rosemary

    Rosemary Senior Member

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    Thanks for your reply...That's good to know that you can do the test from Canada and anywhere in the world....good idea to find out more first to see if its worth it
    FYI ...They recently [FEB 2010] acquired a new sophisticated mass spectrometry machine

    " The Sunderland research unit recently acquired a sophisticated mass spectrometry machine which can identify minute chemical traces in bodily fluids."

    also interesting to know that Mr Shattock who has long suspected a link between the MMR triple vaccine and autism has said he still thinks there is “a possibility”

    http://www.thenorthernecho.co.uk/news/4889878.Autism_link_with_MMR_jab____a_possibility___/

    We are not saying that there definitely is a link, we are just saying we should find out,” said Mr Shattock, who founded Espa after his son was diagnosed with autism.
  19. Rosemary

    Rosemary Senior Member

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    I would be interested in finding out more about elevated levels of a chemical called dolichol ? there is an increase in dolichol levels in CFS... and dolichol can be picked up in a urine test.
    Just therefore wondering if anyone has looked at the dysfunction in the isoprenoid pathway in CFS ? Any Thoughts

    " A report on isoprenoid pathway dysfunction in CFS (Kurup & Kurup, 2003) showed that there was an increase in dolichol levels, carbohydrate residues of glycoproteins, glycolipids, total/individual glycosaminoglycans fractions and lysosomal enzymes in CFS."

    CHRONIC FATIGUE SYNDROME PATIENTS HAVE SERUM N-GLYCOSYLATION CHANGES WHICH MAY REFLECT DOLICHOL DYSFUNCTION
    http://www.abstracts2view.com/eular/view.php?nu=EULAR08L_THU0361
  20. SDP

    SDP

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    In other autism news...

    I saw this in my local newspaper the West Australian (known locally as the 'Worst Australian') and thought it may be of interest:


    http://au.news.yahoo.com/thewest/a/-/wa/7380434/new-gene-find-for-autism/

    The world's biggest DNA scan for autism has uncovered new genetic changes linked to the condition which US researchers say could help doctors diagnose children earlier and deliver improved treatment.

    The results, published in the journal Nature by the Autism Genome Project led by the Mount Sinai school of medicine in New York, could speed the development of the first genetic test for the condition, which affects up to one in 160 Australians.

    A detailed study of almost 1000 children with autism and their parents found sections of the DNA were either missing or duplicated in people with the condition.


    ...

    The results coincided yesterday with the release of a study by Melbourne researchers who found that special brain markers for autism could be seen in a scan known as an electroencephalogram.

    Swinburne University said the scan recorded activity in the brain prompted by visual images and could become a new tool to diagnose autism.

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