I'm in my 4th week of 500mg clarithromycin + 200mg doxycycline daily as part of my lyme disease treatment. Unfortunately i'm noticing lots of side effects and discomfort from the combo. One which really irritates me is that my teeth start to move, they hurt when eating. It started with my wisdom teeth, then my right front teeth and today it's all upper teeth. Has anyone noticed the same side effect from doxycyclin and/or clarithomycin? My liver and spleen also feel enlarged again and i had some intestinal discomfort last week. I'm afraid i don't tolerate oral abx very well and will have to go back on IV!