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Tears Show Inflammation

Discussion in 'Other Health News and Research' started by Ecoclimber, Feb 8, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

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    Mercer Island Wa
    An Interesting discovery and concept

    Salvisberg C, Tajouri N, Hainard A, Burkhard PR, Lalive PH, Turck N.Exploring the human tear fluid: discovery of new biomarkers in multiple sclerosis. Proteomics Clin Appl. 2014 Jan 31.

    PURPOSE:
    Multiple sclerosis is the first cause of progressive neurological disability among young adults living in Western countries. Its diagnosis is mostly based on clinical evaluation, neuroimaging and in some cases cerebrospinal fluid analysis but no definitive diagnostic test exists. We proposed here that the exploration of tears from multiple sclerosis patients could lead to the discovery of new biomarkers.

    EXPERIMENTAL DESIGN:
    Thirty multiple sclerosis patients (20% men) recruited to the Geneva University Hospitals were included in our study (mean age ± SD (years): 42.4 ± 15.9). Twenty five control patients (32% men) were also enrolled (mean age ± SD (years): 42.7 ± 15.1). Tears, cerebrospinal fluid (CSF) or blood was collected for each patient. Three independent quantitative (tandem mass tag, TMT) experiments were carried out between tears from multiple sclerosis and control patients. Protein verification was performed by western blot on tears and CSF and by ELISA on serum samples.

    RESULTS:
    Combined proteomics analyses provided 185 identified tear proteins. Among the differential proteins, alpha-1 antichymotrypsin was the only one to be significantly increased in the 3 experiments with similar ratios (ratios 1.6 to 2.5, p<0.05). Its tear, CSF and serum elevation were further confirmed by western blot and ELISA, respectively.

    CONCLUSIONS AND CLINICAL RELEVANCE:
    This study supports the concept that modifications of the tear proteome can reflect biological abnormalities associated with multiple sclerosis and perhaps other inflammatory conditions affecting the CNS. In addition, alpha-1-anti-chymotrypsin elevation in tear fluid emerges as a promising biomarker for the diagnosis of multiple sclerosis.

    So the question would be if they looked in other inflammatory conditions would it show in their eyes...
    Valentijn, rosie26, alex3619 and 4 others like this.
  2. xchocoholic

    xchocoholic Senior Member

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    Florida
    I wonder how this relates to the chemistry of the tears people shed when in extreme pain. Kidney stoners can relate.
  3. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    An alternative non-invasive test to blood and various other secretions and excretions. Worth investigating further I suspect.

    I wonder if sweat can be similar?
  4. lansbergen

    lansbergen Senior Member

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    With sweat you have the problem bacteria at the skin can influence it.
  5. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Yes, but that might also teach you something. As always, it requires real world testing.

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