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Targeting Pyruvate Dehydrogenase

Discussion in 'General Treatment' started by energyoverload, May 24, 2016.

  1. energyoverload

    energyoverload Senior Member

    Messages:
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    London
    Has anyone had any improvements in myalgia from enhancing pyruvate dehydrogenase activity through the high dose supplementation of specific co-factors:

    Benfotiamine 500mgs every 8 hours
    Alpha Lipoic Acid 600mgs every 8hrs
    Acetyl Carnitine (+) fatty acid oxidation, 1500mgs every 8 hours.

    (also 100mg Riboflavin for FAD and NADH 10mg/D)

    None of the above seem to have any noticeable benefit in isolation, so will determine if any synergistic effect. I have had success in ameliorating severe myalgia using an optimized form of Curcumin, where everything else tried (including ubiquinol, methylation targeted supplements and analgesics) had no marked effect but the cost of curcumin is high.


    http://www.ncbi.nlm.nih.gov/pubmed/3405240
    http://www.ncbi.nlm.nih.gov/pubmed/8596197
    http://www.ncbi.nlm.nih.gov/pubmed/12379317
     
  2. Toove

    Toove

    Messages:
    2
    Likes:
    0
    Oslo, Norway
    So you noticed the pyruvate dehydrogenase problem before Fluge and Mella ... :p
    Congratulations!
    And did your regimen help?
     
  3. Horizon

    Horizon Senior Member

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    307
    NOW has a calcium pyruvate supplement but not sure if that is the same thing
     

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