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Targeting Bacterial Gas Defenses Allow for Increased Efficacy of Numerous Antibiotics

Discussion in 'Other Health News and Research' started by Waverunner, Nov 23, 2011.

  1. Waverunner

    Waverunner Senior Member

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    http://www.sciencedaily.com/releases/2011/11/111117144009.htm

    ScienceDaily (Nov. 17, 2011) Although scientists have known for centuries that many bacteria produce hydrogen sulfide (H2S) it was thought to be simply a toxic by-product of cellular activity. Now, researchers at NYU School of Medicine have discovered H2S in fact plays a major role in protecting bacteria from the effects of numerous different antibiotics.

    In the study led by Evgeny Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry at NYU School of Medicine, researchers found evidence that H2S acts as a general defense mechanism against oxidative stress, the process through which many antibiotics kill bacteria.
    This information provides the basis for developing new techniques to suppress this universal bacterial defense mechanism and make bacteria more susceptible to antibiotics at lower doses. It also paves the way for reversing antibiotic resistance in human pathogens such as Staphylococcus, Pseudomonas, E. coli, and many others.
    The study's findings were published online on November 17 edition of Science.
    "Surprisingly little has been known about H2S biochemistry and physiology in common bacteria" said Dr. Nudler. "We are excited about the potential impact this research may have on the growing problem of microbial resistance. These findings suggest a conceptually new approach, an adjuvant therapy that targets bacterial gas defenses and thus increases the efficacy of many clinically used antibiotics."
    More specifically, the study showed that integrated mechanism of H2S-mediated protection against oxidative stress also protects against antibiotics. The research provides direct support for the emerging concept of the pro-oxidative action of many antibiotics.
    In addition, the study demonstrates that bacteria that generate both H2S and nitric oxide (NO) simultaneously, such as B. anthracis (a causative of anthrax), cannot survive without both gases, even under normal growth conditions. One gas makes up for the lack of the other and at least one of them is essential.
    In a previous study Dr. Nudler and his colleagues demonstrated that NO plays a similar role in protecting bacteria from antibiotics (Science September 9, 2009). However, because NO is present in only a limited number of bacteria while hydrogen sulfide synthesis occurs in essentially all bacteria, the practical implications of this new finding is extremely wide-ranging.
     
  2. Glynis Steele

    Glynis Steele Senior Member

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    Newcastle upon Tyne UK
    Wow, thanks for this Waverunner, very interesting.
     
  3. xchocoholic

    xchocoholic Senior Member

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    Florida
    Thanks .. I wonder if this means taking something that breaks up gas bubbles helps too.

    I always feel much better if I take gas x or something that breaks up the bubbles, but I assumed it was from relieving the gas pressure.

    Is the test for h2s a sibo ? And is there a method to treat these bacteria that doesn't kill good bacteria ?

    Tc .. X
     
  4. Waverunner

    Waverunner Senior Member

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    Good questions, X. The problem with medicine is that we have all kinds of interesting news and updates on certain topics but it takes years till someone puts it into working treatments. It would be possible however to use the theory we have and also apply it to treatments we already have. I guess a specialist or good doctor could help answer these questions.
     
  5. xchocoholic

    xchocoholic Senior Member

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    Florida
    Exactly .. I gave up on waiting for the medical profession to figure this out. Frankly, it's not
    in their best interest to cure us ..

    I read an article awhile back about a peptide found in fermented foods that kills bad bacteria.
    Researchers were trying to get a patent on it .. Yep .. Why eat fermented foods when you can wait
    for the patented peptide ? Lol

    I may have posted it .. I'll look ... Tc .. x

    I'm back .. If you google sciencedaily food preservative you'll find this article. I re-started eating my fermented foods after reading this.
     

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