Update Following doctors orders it was time today to put my Folinic (active folate) up more (which is slowly being increased). So now taking twice per day I "may" be doing a little better since I started all these new things a week or so ago. The other day I missed one of my rest days I usually need every 3rd day and wasnt affected from missing this (which is unusual as I usually always then start crashing when I dont rest up all the third day). Maybe just a coinicidence thou.. still too early to tell. I have the 677 one which is apparently according to Mitchell worst kind of MTHFR. Im also homozygous for it (so have two copies of it not just the one).