Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Taking 1st gen and 2nd gen antihistamines

Discussion in 'General Treatment' started by Skippa, Jul 7, 2016.

  1. Skippa

    Skippa Senior Member

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    Hi all,

    Is it generally considered safe to take a 1st gen antihistamine and 2nd gen antihistamine at the same time?

    I already take a 2nd gen daily, was going to add a 1st for a couple of weeks because reasons.

    Will they interact in a dangerous way? (Eg is there such thing as too much antihistamine?)

    Thanks for any insights :)
     
  2. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

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    A 1st gen antihistamine will cross the BBB. It causes my daughter to crash. I think on other threads I've read you've had issues with SSRIs?

    I've been told that an increased dose of cetirizine is safe.
     
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  3. Skippa

    Skippa Senior Member

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    Hiya, thanks for the response!

    Yes, I have problems with SSRIs. What does that mean in this case?
     
  4. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

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    I'm not a pharmacologist (LOL) but if you have trouble with drugs that alter serotonin chemistry, then 1st gen antihistamines might play with that same balance:
    http://www.ncbi.nlm.nih.gov/pubmed/18363822
    (This is the only reference I can find on that, other than personal experience as a carer).

    Have you tried a 1st gen antihistamine before?
     
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  5. justy

    justy Senior Member

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    I think SOME 1st and 2nd gens can be taken together but not all. Best to ask a doctor I think. Most 1st gens are strongly anticholergenic and Diphenhydramine can block the reuptake of serotonin.
     
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  6. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

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    I would ask a pharmacist.
     
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  7. Skippa

    Skippa Senior Member

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    Thanks folks, I won't take any chances then :)

    Ps, yes I've taken 1st gen before, they tend to make me groggy/drowsy.
     

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