Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
Discuss the article on the Forums.

Taking 1st gen and 2nd gen antihistamines

Discussion in 'General Treatment' started by Skippa, Jul 7, 2016.

  1. Skippa

    Skippa Anti-BS

    Messages:
    841
    Likes:
    2,960
    Hi all,

    Is it generally considered safe to take a 1st gen antihistamine and 2nd gen antihistamine at the same time?

    I already take a 2nd gen daily, was going to add a 1st for a couple of weeks because reasons.

    Will they interact in a dangerous way? (Eg is there such thing as too much antihistamine?)

    Thanks for any insights :)
     
  2. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

    Messages:
    258
    Likes:
    905
    A 1st gen antihistamine will cross the BBB. It causes my daughter to crash. I think on other threads I've read you've had issues with SSRIs?

    I've been told that an increased dose of cetirizine is safe.
     
    Skippa likes this.
  3. Skippa

    Skippa Anti-BS

    Messages:
    841
    Likes:
    2,960
    Hiya, thanks for the response!

    Yes, I have problems with SSRIs. What does that mean in this case?
     
  4. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

    Messages:
    258
    Likes:
    905
    I'm not a pharmacologist (LOL) but if you have trouble with drugs that alter serotonin chemistry, then 1st gen antihistamines might play with that same balance:
    http://www.ncbi.nlm.nih.gov/pubmed/18363822
    (This is the only reference I can find on that, other than personal experience as a carer).

    Have you tried a 1st gen antihistamine before?
     
    Skippa likes this.
  5. justy

    justy Donate Advocate Demonstrate

    Messages:
    5,288
    Likes:
    12,021
    U.K
    I think SOME 1st and 2nd gens can be taken together but not all. Best to ask a doctor I think. Most 1st gens are strongly anticholergenic and Diphenhydramine can block the reuptake of serotonin.
     
    Skippa and Never Give Up like this.
  6. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

    Messages:
    258
    Likes:
    905
    I would ask a pharmacist.
     
    Skippa and justy like this.
  7. Skippa

    Skippa Anti-BS

    Messages:
    841
    Likes:
    2,960
    Thanks folks, I won't take any chances then :)

    Ps, yes I've taken 1st gen before, they tend to make me groggy/drowsy.
     

See more popular forum discussions.

Share This Page