I have a dilemma. I am one of those rare ME patients who's functionality is high enough for the time being that I maintain a job (barely). I'm an attorney. Ever since getting ME in 2011, I've been lucky with the timing of trials. I've never had a trial that coincided with a crash. I've been in relatively functional shape whenever they came around - which is rare - maybe once a year on average. My luck seems to have run out. This Friday I'm due to present a client's case in arbitration and I'm in a significant crash (relatively, for me). Brain fog, sore throat, limb twitches, uncoordination, stinging eyes, swollen lymph nodes and general inflammation. I've over-prepared for the arbitration to the point where I could probably present this case from a hospital bed ... in a coma. So the situation is not so dire that my clients won't get good representation (they will), but I think it's going to be a very long and utterly miserable day. I am confirmed to be immune compromised in several ways: Low NKC function, tested many times; Low CD57; Low IGG subclass 3; candida problems, etc.... All tests out of range. I happen to have some Prednisone that I thought I would never take due to immune suppression. It was prescribed last week, and I filled the prescription just in case. What if I were to take Prednisone for a single day, on Friday, just to tide me over for the day? That's all I need - just one day of reduced inflammation. 1. Do you think 1 day's worth (Edit: 40 mg, not 60 like my original post stated) would be dangerous to an immune compromised person? 2. Do you know any alternatives that might buy me one day of better functionality, even if I have to pay for it a little bit afterwards? I take full responsibility for my final decision. I'm not relying on anyone's advice, I'm just looking for others' experiences and knowledge base. Edit: I hope it isn't insensitive to post about a problem that some patients might wish they were in a position to have.