Certainly have my fingers crossed for you too, Jackie! You deserve a break! I've said this before on here, but will repeat anyway. My Vit D was checked for the first time last September, and my level was 7 (using the same normals as you quoted 32-100). My doc put me on D3 5000 IU every other day, so pretty close to what you are getting. Within 7 weeks (Nov) I was up to 23. She wanted me to continue on the same dose and recheck in 6 months (which seemed kinda long, so I may check with her on that). Anyway, I went off all Ibuprofen at the same time because of abnormal creatinine and electrolytes. Only pointing that out because that's the only other change made at the same time I started D3. Whether due to the Vit D, I don't know, but the OI is better (not gone) and my crashes aren't quite as bad either. Kinda hard to explain. I don't have that internal vibrating feeling for one thing and haven't had that "gee, I have to be dying, feeling". So could that be due to Vit D? I dunno, but I'll take any little improvement anytime.:Retro smile: One good thing is the D3 didn't seem to bother me at all. I'm so sensitive to stuff now, I was leary of trying it. I haven't been able to stay up really any longer than I did previously, but it's not the same awful feeling as with the bad OI. Maybe a lot of deconditioning. Also, I really miss the Ibuprofen because taking that regularly kept a lot of the joint pain and periodic costochondritis at bay - so those things cause problems when trying to move around. Other pain meds just don't work that well for chronic inflammation. I'm really hopeful that Tagament and D3 have some postitive impact for you!! Will keep everything crossed!