Agents for Change: The 10th Invest in ME International ME Conference, 2015 - Part 1
The 10th Invest in ME International ME Conference (IIMEC10) was held, as usual, in the Lecture Theatre at 1 Birdcage Walk in Westminster on May 29th, 2015.
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Tackling ME/CFS in New Zealand by the Principles of Precision Medicine

Discussion in 'Latest ME/CFS Research' started by Bob, Jun 6, 2016.

  1. Bob

    Bob

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    Below are the details of a report in the new 2016 conference version of Invest in ME's journal. The report starts on page 46.

    The report details an interesting biomedical study, being carried out in New Zealand, involving proteomics, cytokines and miRNAs. It sounds fascinating.

    Invest in ME - The Journal of IiMER 2016
    http://www.investinme.org/Documents/Journals/Journal of IiME Vol 10 Issue 1.pdf

    Extract from the report:
    The study is supported by ANZMES. The Associated New Zealand ME Society Inc, Auckland, New Zealand. http://www.anzmes.org.nz



    Forum discussion thread for the journal:
    http://forums.phoenixrising.me/inde...journal-of-iimer-2016-conference-no-11.45036/


    .
     
    Last edited: Jun 6, 2016
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  2. Hutan

    Hutan Senior Member

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    For those of you not familiar with Prof Warren Tate and interested to find out more, this video is good. His daughter has ME/CFS.



    Edit: Just watching it again, it's interesting to note that (20?) years ago he tried to get funding for a study on mitochondria in ME/CFS - but the medical profession and funding bodies just weren't interested in ME/CFS.
     
    Last edited: Jun 6, 2016
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  3. Cohen2

    Cohen2 Senior Member

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    I am lucky enough to now be a patient in Prof Tate and his team's ongoing Me/cfs study after meeting him at a talk he gave. He was updating the local support group on the progress that had been made in the study. Unfortunately I've forgotten the details but they have found differences between controls and M E patients. I will try to get the details to update the forum.

    The next stage of the study is using a Seahorse machine to look at Bioenergetic Health index in live blood cells (a measure of energy production). He and his colleagues still can't get funding from the government.

    He is also in contact with Ron Davis, who showed an interest in the study at the International conference. I believe they will be sharing findings etc. I'm stoked to be part of this.

    @Hutan, you may be interested in this
     
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  4. daisybell

    daisybell Senior Member

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    @Cohen2 do you have to be based in Dunedin for this?
     
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  5. Snowdrop

    Snowdrop Vexacious, thy name is PACE

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    I'm wondering if there may be some non disclosure issues around being in the study if they want to publish the data down the road.

    Glad to hear that there is some good research going on in NZ too.
     
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  6. Cohen2

    Cohen2 Senior Member

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    they've been open with their findings so far. Or would the issue be me saying I'm in it?
     
  7. Cohen2

    Cohen2 Senior Member

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    yeah I think so
     
  8. Snowdrop

    Snowdrop Vexacious, thy name is PACE

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    I don't know. There have been questions regarding sharing info on other threads about ongoing research but maybe different issues.
     
  9. Hutan

    Hutan Senior Member

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    Thanks for this, I look forward to hearing more about what Prof Tate spoke about.

    Do you have a contact email or phone number for the study? I'd travel to Dunedin to participate if it's possible.
     
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  10. Cohen2

    Cohen2 Senior Member

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    I'll look into this before posting any more details
     
  11. Cohen2

    Cohen2 Senior Member

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    I think they have all participants they need/ can afford.
     
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  12. Cohen2

    Cohen2 Senior Member

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    Heres some slides from a talk Prof Tate gave in November on his and his collegues research. He has given me permission to post them. They may be hard to follow as they were used to aid his talk.

    upload_2017-1-11_21-36-1.png
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    upload_2017-1-11_21-37-44.png
    upload_2017-1-11_21-38-22.png

    upload_2017-1-11_21-39-22.png

    Sorry that one slide is impossible to read
     

    Attached Files:

    Last edited: Jan 11, 2017
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  13. Cohen2

    Cohen2 Senior Member

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    upload_2017-1-11_21-41-51.png
    upload_2017-1-11_21-42-16.png
    upload_2017-1-11_21-42-45.png
    upload_2017-1-11_21-43-7.png
    upload_2017-1-11_21-43-27.png
    upload_2017-1-11_21-43-46.png
    upload_2017-1-11_21-44-9.png
    upload_2017-1-11_21-44-32.png
     
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  14. Cohen2

    Cohen2 Senior Member

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    upload_2017-1-11_21-45-30.png
     
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  15. user9876

    user9876 Senior Member

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    I'm concerned that they talk about their model predictions but I assume their model was trained on the data so they are effectively reporting how well they can train a classifier to separate out their dataset.

    This in itself is interesting but to claim performance figures or a classifier (or predictor as they call it) conventionally you need to use three data sets. A training set used to train the model or set of models. A test set used whilst looking at different model parameters and generally optimizing what works and a third verification set from which results are quoted once the models have been chosen and optimized.

    The data does look interesting but very small sample size.
     
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  16. Mel9

    Mel9 Senior Member

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  17. Snow Leopard

    Snow Leopard Hibernating

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    The cytokine results are uninteresting, but I am interested in seeing the rest of the results, particularly the gene expression results.

    Those mRNAs are different to what have been reported in previous studies, but there isn't always overlap between the candidates in such research.
     
  18. Cohen2

    Cohen2 Senior Member

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    They do plan on increasing the sample size but will need more funding
     
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