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T-Cell Super-Enhancers and Autoimmunity

Discussion in 'Other Health News and Research' started by nandixon, Mar 17, 2015.

  1. nandixon

    nandixon Senior Member

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    Has this already been posted somewhere?:

    NIH researchers reveal link between powerful gene regulatory elements and autoimmune diseases



    (More info in the links.)
     
    garcia, Valentijn and August59 like this.
  2. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I find this a bit baffling. There is no evidence for anything wrong with T cells in RA, despite lots of immunologists being obsessed with this idea. Moreover, the genetic risks for RA do not lie in superenhancers - the main ones are the X chromosome (being female) and MHC Class II, expressed on B cells and other antigen presenting cells. This sound to me like somebody has found some bits of DNA and wants to make it sound as if they are important to a disease so that they can get grant funding!!
     
  3. nandixon

    nandixon Senior Member

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    Here is the abstract from PubMed (with a link to the same abstract in the original journal). I've broken it up for easier reading:

     
    Last edited: Mar 18, 2015
    garcia likes this.

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