Since standard Lyme lab tests are insensitive and inconclusive what I read is that LLMDs primarily use clinical information to diagnose, but to me this seems to not make a great deal of sense because wouldn't they then diagnose most if not all CFS sufferers with Lyme disease? I read a few official Lyme symptom lists and they are pretty much 100% identical to CFS except the initial rash which doesn't occur in many Lyme cases anyway. I think it's extremely important to know definitively whether you have Lyme or not if you are suffering from CFS. The reason is because if you do have Lyme then it's quite possible that Lyme was the root cause of your CFS (unless you got it well into your disease), and other co-infections you might have were brought on because Borrelia is weakening/suppressing your immune system therefore allowing things like latent viral infections reactivate. Unlike most other subsets of CFS where we actually don't know what the root cause is, if you were infected with Lyme it's a plausible theory that it was the root cause and over time weakened your immune system then causing other infections, etc and bring on CFS. So if you treat the Lyme effectively (along with the co-infections) you will have a greater chance of full recovery. Otherwise if you treat everything else and test negative for Lyme but still have it then everything will come back and you will have wasted your time. I was wondering if anyone could shed some light on any symptoms or clinical information that are specific to Lyme that differentiate it from other CFS types? There has to be some clear differences and for some reason I find it very hard to find answers to this on the web.