i've been taking high doses of mthf and mb12 since april and improving moderately (20%). i've been tinkering recently and have started feeling worse and am unsure what is responsible/why. what do you all think? details below recently i added some sam-e and felt great (strong!) for a few days until i developed headaches and insomnia, stuffiness, and flaky dry skin which is very unusual for me. to speed clearing the sam-e, i added 20 mg p5p 2x/day and bumped up my dose of mthf to 20 mg/day from 15mg/day. the symptoms went away. i had been sporadically taking p5p previously, and felt like it gave me a mild boost in energy- it seemed to speed methylation and clear up nasal congestion (i believe it speeds clearing of histamine) does p5p increase the need for mthf? since then, for the past 2 weeks, i've continued to take the 40 mg p5p, 20 mg mthf in addition to my usual: 4 mg mb12 sq, vitamin e, fish oil, curcumin, lactoferrin, ala, alcar, coq10, biweekly hydroxyb12. none of these have changed. i also started and stopped vinpocetine, in case that was creating the symptoms. over this period i've experienced the worsening of these symptoms: brain fog/spacey feeling harder to read vertigo… i live near a faultline and thought we were experiencing small earthquakes for a few days dry lips (face/scalp not noticeably dry as during sam-e) increased noise sensitivity headaches muscle twitches a few days ago but this resolved w/ a little potassium. rare for me. worse memory and eyesight what do you think is going on? i thought, probably... too much p5p too much folate too little folate (linked to too much p5p?) too little mb12? (linked to too much mthf?) i just took around 100 mg niacin on the off chance that i was overmethylating... felt uncomfortable flush and feel a bit tired and irritable after. i don't think that was the problem though... i'm planning to cut out the p5p and drop down the mthf back to 15 mg.