Why do you think you have high COMT activity?
I don't.. I'm just trying to figure things out.
What I do have is a hetera C677T MTHFR gene mutation and I suspect slow COMT but I haven't got COMT tested yet.
Terrible under stress and a lifetime of brain fog.
I also have symptoms of high estrogen but a recent test confirmed that Testosterone, Estrogen, and Progesterone are all very low. However, Estroget / Testosterone ratio are optimal.. Of course they are optimal, I'm grown fat almost primarily on my chest.
If I am overmethylating (MTHFR: too much dopamine, seratonin etc) and have slow comt, I would have symptoms of anxiety and depression, bran-fog etc.
Maybe my whopping weight gain and impossibility of lowing it comes from low levels of histamine (histapenia) though I haven't had that tested yet but will.
I asked the question above because I'm trying to establish the link between MTHFR, COMT and weight gain.. All I have found on the web is sweeping statements about how slow COMT doesn't metabolize estrogen efficiently.. So wouldn't I then be estrogen dominant.. My test results say otherwise but I'm still getting fat and can't lose it. Half of it seems to go to and stay on my chest.