I was doing ok until my husband had to work away from home, so I picked up all the house jobs and pet care during the week. Added to this my father has cancer and is very sick. I was ok for three weeks, and then I started noticing that I was doing more silly things with the brain fog, like trying to cook a pancake on a ring without turning it on. Then a few days later I clipped my hip on the corner of a table and cut it badly. Then after a month I woke up in the night with vertigo, breathlessness,my sleep gradually went from reasonable to hopeless, and the night sweats began again- drenching ones too. The muscle pain got worse and the joint pain too. Then there were the dreaded headaches. Then the worst thing happened- I had to go to The Post Office, which I did drenched in sweat. I had a sort of panic attack in the queue, which I think was the OI as I felt my heart racing, and I had to leave abruptly to find the nearest toilet for the dreaded bowel event- diarrhea. Has anyone had this with their OI?- it happens to me a lot especially if I stand in hot weather if I have recently eaten. So here I am 5 weeks into a year of being alone in the week and my symptoms are back really intense. A few weeks ago I almost thought I could return to a part time job, but it has only taken 5 weeks of this extra work to see an increase in symptoms to this level. I've had this disease for 15 years now and have seen many relapses in that time. Can anyone else identify with how these symptoms build from minor to horrendous as you take on more things? I had a couple of social visits in the week leading up to the crash as well, which I now think added to the work I had to do, as well as the effort involved in holding conversations. I think this has to stop now as although isolating it seems to prevent crashes. I guess it is a warning to us all to make sure we are really ready before we commit to something, as a mild day of symptoms doesn't mean that we are guaranteed to be on the road to stability. So my pattern went from ok to more brain fog- more muscle pain- flu like- night sweats- panic attacks- more OI- diarrhea - breathlessness- dreadful sleep. Does this ring any bells with anyone else who got themselves into a reasonable state and then went downhill. It has happened to me so many times, but in a good spell I forget about it and just plod on with minor symptoms not thinking they are a warning.