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Symptoms and Cortisol - a causal relationship?

Discussion in 'General Symptoms' started by MartinDH, Nov 17, 2017.

  1. debored13

    debored13 Senior Member

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    i mean try pregnenolone
     
  2. sb4

    sb4 Senior Member

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    You can order adrenal saliva tests without Drs permision. They are about £100 and show your cortisol throughout 4 points of the day.
     
  3. Learner1

    Learner1 Professional Patient

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    Taking hydrocortisone will get you moving if your body isn't producing enough cortisol. It works pretty well to take small amounts as a physiological replacenent dose.

    Taking pregnenolone can help reduce brain fog and it can drop down into cortisol production. However, it can be unpredictable in where it goes. In me, it doesn't help cortisol and instead all goes to estrogen, and in another PWME I've talked with it all went to testosterone for her.

    Its a delicate balance...
     
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  4. bertiedog

    bertiedog Senior Member

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    This is so true and I think many people aren't aware of how unpredictable taking pregnenolone can be you just don't know where its going to end up. If you have fully functioning pathways (unlikely with our illness) then it could eventually end up as more cortisol but with me it just ends up with more progesterone and never gets to cortisol where its needed it.

    Have always had high levels of progesterone even post menopausal because of this issue with the pathway and presumably enzymes that aren't doing their job properly so I just have to take the real thing which for me is 6 mg Prednisolone daily.

    Pam
     
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  5. ukxmrv

    ukxmrv Senior Member

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    It seems to be related to the low cortisol as light in the morning (be in sun or artificial) makes the whole thing worse (sickness/shaking, low BP, spots in front of yes. weakness, dizzyness) worse. In the years I was able to work (and in the sunlight) I would throw up in public if I pushed it too much.

    Been like that for over 30 years now and other family members are the same. There's no getting used to it sadly. We can tolerate the sun as the day progresses and the symptoms stop.
     
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  6. debored13

    debored13 Senior Member

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    that's
    that's interesting... ray peat hates estrogenic stuff but loves pregnenolone lol
     
  7. debored13

    debored13 Senior Member

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    Vermont, school in Western MA
    I have, I have consistently low cortisol and high DHEA
     
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  8. debored13

    debored13 Senior Member

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    but I meant under a doctor's supervision so that they can monitor me for side effects
     
  9. debored13

    debored13 Senior Member

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    does hydrocortisone raise bp? i was under impression pregnenolone caused less side effects than corticosteroids
     
  10. Learner1

    Learner1 Professional Patient

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    Hydrocortisone hasn't had much of an effect on my blood pressure, which tends to run high due to adrenergic antibodies. People with low BP are put on fludricortisone, aka Florinef, for low BP and POTS.

    Pregnenolone didn't seem to improve my cortisol production. It's a little unpredictable which pathway it goes down.
     
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  11. debored13

    debored13 Senior Member

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    i have had a couple white coat hypertension episodes but i think overall BP normal but i don't wanna have to monitor it that much
     

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