Ema, I know the "over thinking" place you are in and it is awful!! I do agree that you have to collect your information and make the best decision you can what is in front of you a the time. Then just go for it!! Also, do you think your insurance would approve the Famvir dose and add in some Acyclovir? My doctor was crazy for Valcyte. He insisted it was the only anti viral that would get deep enough to really impact these virus' and cross the blood brain barrier. He tried to talk me into starting it again at every visit. He acted like with my huge load of HHV6 that my Famvir almost useless. My HHV6 dropped from the highest he had ever seen (and he has treated over 500 people with Valcyte and these virus') to almost in the normal range. SO, it is not true that the other anti virals dont help with the more serious cases of HHV6 and such. Now, in the last few years and after some on going contact with Montoya and treating some others with Famvir, my doctor began only using Famvir. He doesnt use Valcyte at all anymore. He was a hard core Valcyte doc too!! Now, because of insurance issues, he has gone to the Acyclovir at 1,600 mg with food twice a day. I think they are finding this with food thing important to help the anti virals work better in some way. I always thought Acyclovir was useless but for my doctor, who put every chronically ill person with any sign of these virus' on Valcyte, to switch and feel so confident with getting the same results is HUGE. I personally would start with the Famvir dose your insurance will approve for awhile, test in about 6 months and decide what to do from there. I have to say I got a head ache and sore throat when I started this big dose of Acycolovir. It didnt make feel like I was dying like Valcyte. Famvir at 500 mgm 3x a day gave me no symptoms at all. Acyclovir is the only thing that gave me "acceptable" symptoms that made me feel it might be doing something but wasnt killing me off slowly. Maybe it does have value in this whole bug killing thing. It is cheap too so insurance has no problem covering it. Blood tests will show if you are making progres. Whatever you decide to do...BEST OF LUCK!!!!!