I posted the message below as a response to another thread, fyi, but here goes: I could not tolerate the generic Valtrex @ 1 g, 3x/day. I am not generally intolerant to or particularly sensitive to meds as a rule; however, I am not a very large adult (5'6", appx. 114-120 lbs). Recently my EBV Early Antigen level flagged high on an EBV panel blood test my doctor ordered and thus, the EBV has reactivated / is reactivating. My specialist took me down to 500 mg., 2x/day of Valtrex (Brand name this time) temporarily--for about 2 weeks, until I felt okay to go to 500 mg., 3x/day and then titrate slowly back up to the initial dose. I was given clear instructions to take each dose after a full meal only. This time, I was also rx'ed Zantac (300 mg), to take before each meal in which I was taking the Valtrex dose afterwards. I was told the Zantac can help with peptic side effects, but also helps to increase absorption of the Valtrex in the system. Still, I wasn't doing too well with the Valtrex. So yesterday, my Specialist prescribed a new protocol for me. (Personally, I had not heard of it yet, but it sound promisingand makes sense to me thus far). I am now rx'ed Acyclovir, 800 mgs., 4x/day. (However, I am beginning with 2x/daytostart with). I have been given instructions to crush each tablet extremely well & then stir &dissolve it into a few ounces of warm water. I am not to swallow this mixture, but rather"swish" it around in my mouth for 3 min. & then spit out. I can rinse my mouth out with water, etc. when I'm done, too. If all goeswell, I will I begin doing this 4x/day and for 6 mos. on the full dosage. I am still to take the Zantac as well. This method is said to help bypass many of the potential side effects that I may face by just swallowing it. One of his nurses walked me through the phone had personally via phone yesterday.She followed the same protocol and is functioning at a "normal" level and saideven feels quite peppy often now (whichher demeanor/voice does seem to radiate, haha). She also gave me some awesome tips & tricks for following the protocol on the go and so forth. I am feeling optimistic about this so far.