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Swedish trial of mercury binding substance IodoCarb ® for CFS

Discussion in 'Active Clinical Studies' started by Dolphin, Feb 8, 2013.

  1. Dolphin

    Dolphin Senior Member

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    (I've copied a computer-generated English translation below. No questions to me, please - I just came across it on Twitter)

    https://www.avanza.se/aza/press/news.jsp?newsArticleId=N1964331

    Computer-generated English translation:

    https://www.avanza.se/aza/press/news.jsp?newsArticleId=N1964331

     
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  2. lnester7

    lnester7 Seven

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    What is the theory behind this drug, that we have a mercury binding issue???
     
  3. Helen

    Helen Senior Member

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    Hi Inester7,

    They have noticed that people with CFS have about the same symptoms as people intoxicated by mercury (exposed in their jobs). As Iodocarb binds to mercury, and some people have gotten better when they tried the supplement, they now want to test if this group of people with CFS could get better from using it.
    They don´t discuss if we have a mercury binding issue. They just suggest that a toxic overload might give us CFS.

    Most people with ME/CFS, according to more than 200 Methylation Panels analysed by Rich Van Konynenburg, have a partially blocked methylation, with decreased level of glutathione. As glutathione binds to mercury, we also have "a mercury binding issue" , when low levels of glutathione.

    I live in Sweden so I will follow the study carefully and let you know the results. Thanks Dolphin for the reminder!

    Helen
     
  4. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

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    That is the best computer generated translation that I have seen. What site/software did you use to do it?

    I'm a little suspicious of the responsible physician being a psychiatrist.
     
  5. Dolphin

    Dolphin Senior Member

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    Yes, I was surprised by it also.
    It was Google Translate (on Google Chrome).
    I was wondering perhaps was it written by somebody initially in English and translated into Swedish which might then improve a translation? I've also seen with some translation tools one can suggest better translations of particular bits, so perhaps somebody did that already???
     
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  6. SilverbladeTE

    SilverbladeTE Senior Member

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    Somewhere near Glasgow, Scotland
    hm, interesting!
    well I've used Selenium for while, ti seems to helps, I have a load of amalgam fillings and live in an incredibly heavy metal polluted area so I gave selenium a try as it's useful at removing mercury.
     
  7. Mimi

    Mimi Senior Member

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    You don't have to use a translator - it's posted here: http://www.clinicaltrials.gov/ct2/show/record/NCT01793415

    The summary is:

    Descriptive Information
    Brief Title ICMJE Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®)
    Official Title ICMJE Phase 1 + 2a Proof of Concept Study of Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®)
    Brief Summary
    Chronic fatigue syndrome (CFS) is a devastating and complex disorder. People with CFS experience overwhelming fatigue and a host of other symptoms that are not improved by bed rest. Interestingly, many of the symptoms experienced by people with CFS are identical to symptoms caused by long-term low-level exposure to mercury, which is called micromercurialism.
    This study will examine if the mercury binding substance IodoCarb(r) can improve the health of patients with CFS.

    Detailed Description
    Chronic fatigue syndrome (CFS, which is also sometimes called ME, Myalgic Encephalomyelitis) is a devastating and complex disorder. People with CFS experience overwhelming fatigue and a host of other symptoms that are not improved by bed rest and that can get worse after physical activity and mental exertion. They often function at a substantially lower level of activity than they were capable of before they became ill. Besides severe fatigue, other symptoms include muscle- and joint pain, impaired memory or mental concentration, insomnia, and post-exertion malaise lasting more than 24 hours. Often, CFS can persist for many years. Researchers have not yet identified what causes CFS, and there are no specific tests to diagnose CFS. The prevalence has been suggested to be around 1-2 %.
    All humans are exposed to small amounts of mercury every day from the environment. It is well-known that exposure to mercury in small quantities for a long time can affect the psychic function, and cause severe fatigue, insomnia, lack of concentration and memory problems, which is called micromercurialism. It is also known that the sensitivity to the toxic effects by mercury differs greatly between people. Thus, it is quite possible that the small amount of mercury that humans are exposed to daily are sufficient to lead to micromercurialism symptoms in sensitive individuals. Therefore, the question arises if a reduction of the mercury content in the body of CFS patients can improve their symptoms and problems in daily life.
    This study will examine if the mercury binding substance IodoCarb(r) can improve the health of patients with CFS.
    This is a double blind placebo controlled parallel group study.
    Patient population: 40 patients diagnosed with CFS will participate.
     
  8. Mimi

    Mimi Senior Member

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    I have been doing Cutler frequent low-dose chelation to get rid of mercury and it has helped me more than anything else, with the possible exception of s-acetyl glutathione. Or maybe idebenone.
     
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  9. A.B.

    A.B. Senior Member

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    I don't think iodated activated carbon can lower the body burden of mercury in any organs except the gut.

    Iodated activated carbon could end up alleviating symptoms for a number of reasons, but the study design does not allow any conclusions to be made about mercury being involved as far as I can tell.

    I don't want to come across as too critical though, I think trying new approaches is commendable and for this reason alone the study is worth watching.
     
    alex3619 likes this.
  10. Mimi

    Mimi Senior Member

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    It doesn't need to. The gut is extremely well-vasculated, so something in the gut can pull mercury from the blood. The blood is in turn supplied with mercury from the tissues. For more info, watch some of Chris Slade's videos on YouTube.
     
  11. A.B.

    A.B. Senior Member

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    That's how layman imagine it works, but it doesn't. If it did, micromercurialism wouldn't exist because the blood clears itself of mercury within a few days.
     
  12. Mimi

    Mimi Senior Member

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    You mean me, or Chris Slade? While I am a layman (albeit and educated one) Dr. Slade has a PhD in chemistry. He did his dissertation on mercury detoxification. He consults with Hal Huggins and Dietrich Klinghardt and has done a lot of original research in the field. All of his statements are backed up by evidence, using the world's most sensitive mercury testing to date.

    Dr. Slade has shown how mercury levels drop in the bloodstream during chelation, and then rise back up as they seep out of the tissues into the blood. Furthermore, he has the only test that I know of which can distinguish between forms of mercury stored in the body - methyl, elemental or an inorganic salt. This gives us clues as to source and location - something no other test can do.

    The beautiful thing about that test is it's totally safe. No drinking DMPS or DMSA and then retoxifying the body by moving mercury around and making things worse. Furthermore, his company's product - Quicksilver Scientific Intestinal Metal Detox - is much, much safer than chelators that go in the blood. And it doesn't pull out minerals the way DMPS and DMSA do.

    If you have ME/CFS then this is well worth looking into. Mercury is everywhere and we are constantly getting re-exposed. If you have ever had amalgam fillings, they are 50-70% mercury. And even if you have had them removed safely - following very strict protocols that few dentists are trained in - you still have a body burden of mercury to detox. Something we don't do very well.

    As for the blood clearing itself of mercury - which I assure you it does not - where do you think that mercury goes? If you have ME/CFS by definition your detoxification systems are overloaded. Mercury accumulates in those systems and screws them up. It has an affinity for the heart, liver, brain, thyroid and adrenals. And now that we have better testing, we know it stays in the blood.
     
  13. dannybex

    dannybex Senior Member

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    Mimi, I agree that the test sounds promising, however it's my understanding that his 'instestinal' product isn't considered "much, much safer" than say ALA, which Cutler as you know, used and recommends. I had heard that it's only used once or twice a day, which would have the ALA in it redistributing mercury in the body. Do you have any info to back up the 'safer' claims? And/or have you asked about this on the FDC yahoo group?

    Thanks in advance Mimi,

    Dan
     
  14. Mimi

    Mimi Senior Member

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    Hi Dan - It's been a while since I borrowed the Cutler protocol, but if I recall correctly, ALA doesn't bind mercury as strongly as DMSA. That's why he suggest taking them together, and taking DMSA every four hours around the clock.

    I did 7 rounds of the Cutler protocol this spring, and added ALA on the last two rounds. My experience was that ALA greatly increased my symptoms temporarily, to the point where I was nearly as sick as I was in the first two rounds.

    If ALA moves mercury in the brain, as Cutler contends, that would probably explain it. Given the strength of the reaction, I'm glad I was taking DMSA around the clock, along with s-acetyl glutathione, coffee enemas, charcoal, diatomaceous earth, Pectasol, NDF+, Liver Life, and so forth. Even so, the mercury kicked my butt right until the final day of detox.

    Regarding your last two questions, I didn't know about the Yahoo forum, but I'm glad there is one. For safety information, I recommend Chris Shade's in-depth presentations. His work is very thorough.

    Mimi
     
  15. dannybex

    dannybex Senior Member

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    Interesting, thanks for replying Mimi.

    I did about six-seven rounds of ALA back in late 2009 -- wish I could turn the clock back and continue where I left off. I had no problems with it at all -- even waking up at night to take a dose wasn't so bad -- and generally felt "better" during during that time. So in hindsight, I took my "health" for granted, and stopped chelating because...I dunno...I wasn't as sick as other locals with CFS so I guess I thought I knew everything. Hindsight's always 20/20, but sure wish I hadn't wasted these last four years...oy! :)

    It's my understanding that ALA does bind mercury as well as DMSA, and is in Cutler's view the only compound that can cross the BBB, but that DMSA may help lower the overall body burden relatively faster. Sometimes it's recommended to start with (can't remember why right now!), although Cutler used ALA alone when he chelated. It was too pricey for me, so I went with low dose ALA.

    I'd recommend checking out the FDC group. I believe you can check out the posts without joining, so if you're interested in hearing contrasting opinions on the safety (or not) of various compounds claimed to chelate. Let's just say for example, that NDF -- or worse, anything with chlorella or cilantro -- isn't looked at very fondly.

    Thanks -- I'll check out more of Shade's videos...hope he has some info on the ingredients in his products.
     
  16. Sparrowhawk

    Sparrowhawk Senior Member

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    Just researching this based on Mim's recommendation. The Chris Shade videos on youtube are quite clear and enlightening about mercury in our metabolism and how to get it out. Do you know if anyone on Phoenix Rising has used his approach/product?

    dannybex can you give me any more info on where to find that yahoo group? Is that an acronym or abbreviation of a longer group name I can search on? Thanks.

    and Mimi when you say you did rounds of the Cutler protocol, how many days in a row is each round, over how many weeks or months? Thanks again.
     
  17. dannybex

    dannybex Senior Member

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  18. Sparrowhawk

    Sparrowhawk Senior Member

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    Thanks very much on both accounts! Just joined there. Between this and the MTHFR stuff I'm a bit overwhelmed but it's all so intertwined. One practitioner is telling me all the viral issues will work out once my mercury burden is reduced, others are saying do antivirals...and there's debate around the safest way to do mercury chelation...argh.
     
  19. Mimi

    Mimi Senior Member

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    Hi Sparrowhawk,

    I did it based on muscle testing as well as intuitive reading, so not the standard Cutler protocol. My rhythm was 3 days on and 2 days off. And it was hell. Just to warn you.

    Mimi
     
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  20. Mimi

    Mimi Senior Member

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    I also have another friend on PR who is doing the Quicksilver protocol. He's quite happy on it and expects to go back to work in October.
     
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