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[Sweden] Opinion piece: B12/B9 – possible treatment for mental fatigue

Discussion in 'General ME/CFS News' started by mango, Jul 11, 2017.

  1. mango

    mango Senior Member

    An opinion piece in Läkartidningen (Swedish website for doctors), written by professor emeritus Björn Regland: "Vitamin B12/B9 -- possible treatment for mental fatigue"

    Vitamin B12/B9 – möjlig behandling vid mental trötthet

    ETA references:

    1. Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Br J Nutr. 1973;30(2):277-83.
    2. Brenu EW, Staines DR, Marshall-Gradisnik SM. Methylation profile of CD4+ T cells in chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Cell Immunol. 2014;5:228.
    3. De Vega WC, Vernon SD, McGowan PO. DNA methylation modifications associated with chronic fatigue syndrome. PLoS One. 2014;9(8):e104757.
    4. Naviaux RK, Naviaux JC, Li K, et al. Metabolic features of chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2016;113(37):E5472-80.
    5. Regland B, Andersson M, Abrahamsson L, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26(4):301-7.
    6. Regland B, Forsmark S, Halaouate L, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10(4):e0124648.
    Last edited: Jul 11, 2017
  2. PinkPanda

    PinkPanda Senior Member

    I have the biggest benefits from sublingual hydroxocobalamin, I don't have that good reactions to other b12 forms. It makes me feel that sufficient hydroxocobalamin intake is important. Don't know if it would make a difference to get injections.
    And I can also agree that it's a helpful combination taking b12 and methylfolate. I don't have good reactions to taking b6 or amino acids though.
    This text does confirm that methylation and homocysteine are important issues to look at.
    trishrhymes likes this.

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