I think i mentioned it on another thread but if sub sets are high can indicate immune system fighting something? and cd8 is common with ebv and cmv. If sub sets low then immune system tiring out. Be interesting to see how your dhea/cortisol is going, dhea can help with immune function etc. I dont think anyone can fully understand t-cells, b-cells etc. b-cells from memory make antibodies to infections/past infections etc where t-cells and nk cells dont make antibodies but fight infections more directly, nk cells i think are a type of t-cell where b-cells are different to t-cells, so adding them may give u a number greater then 100% if that makes sense. Total lymphocytes although within range are low, i wonder how immunoglobulin/gammaglobulin would improve your immune function?? Heres a link to an old cfs study that might interest u on t-cells, b-cells, coxsackie virus, herpes viruses etc http://www.cfids-cab.org/mess/lymphocyte.htm cheers!!!