Dr Light gave the most exciting presentation at the Reno conference in March. Apparently nobody in the scientific community until recently had any clue how the brain learns when our muscles are overworked. They knew that when the brain believes that damage is about to occur it will flood the body with pain and fatigue signals in an attempt to stop whatever activity is going on. There is little evidence, however, of overt muscle damage in CFS. But what if the sensory system that determines if the muscles are damaged is off? What if it is overreacting to even very very small signs of muscle damage - signs that are produced even during mild exercise? What if the brain thinks the muscles in CFS patients are on the verge of collapse and is acting accordingly? That is what Dr. light has evidence of - signs that CFS patients have many times the number of receptors that measure such things as lactic acid and ATP than normal people. This suggests that they're reacting to small amounts of muscle activity as if people had just a marathon. What a stunning finding! And still very preliminary. More when the last overview of the conference is produced.