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Suppressing B Cells vs Depleting them

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by AdamS, May 13, 2017.

  1. AdamS

    AdamS Senior Member

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    This could be a completely silly question so apologies in advance, but given that a number of responding ME patients treated with Rituximab report improvements followed by relapse when their B cells come back, are there any drugs out there that could:

    • Suppress circulating B cells to a point where clinical improvement is seen.
    • Disrupt B cell signalling somehow.
    • Do something else to B cells that might benefit us.
    All replies greatly appreciated!
     
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  2. Cheesus

    Cheesus Senior Member

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    I am sure my answer will be overshadowed by someone with far superior knowledge, however one method that might be useful is to attempt to boost regulatory B-cells somehow. These are part of the body's natural immune suppression mechanism.
     
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  3. Jesse2233

    Jesse2233 Senior Member

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    Rapamycin is one drug that comes to mind
     
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  4. deleder2k

    deleder2k Senior Member

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