Gut Microbes. 2016 Nov 3:0. [Epub ahead of print]
Support for the Microgenderome Invites Enquiry into Sex Differences.
Wallis A 1, Butt H 2, Ball M 1, Lewis DP 3, Bruck D 1.
Abstract
The microgenderome defines the interaction between microbiota, sex hormones and the immune system. Our recent research inferred support for the microgenderome by showing sex differences in microbiota-symptom associations in a clinical sample of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). This addendum expands upon the sex-specific pattern of associations that were observed. Interpretations are hypothesised in relation to genera versus species-level analyses and D-lactate theory. Evidence of sex-differences invites future research to consider sex comparisons in microbial function even when microbial abundance is statistically similar. Pairing assessment of clinical symptoms with microbial culture, DNA sequencing and metabolomics methods will help advance our current understandings of the role of the microbiome in health and disease.
KEYWORDS:
D-lactate; chronic fatigue syndrome; clinical symptoms; microbiome; myalgic encephalopathy; neurological manifestations; sex differences
PMID: 27808584
DOI: 10.1080/19490976.2016.1256524
https://www.ncbi.nlm.nih.gov/pubmed/27808584
http://www.tandfonline.com/doi/full/10.1080/19490976.2016.1256524
Support for the Microgenderome Invites Enquiry into Sex Differences.
Wallis A 1, Butt H 2, Ball M 1, Lewis DP 3, Bruck D 1.
Abstract
The microgenderome defines the interaction between microbiota, sex hormones and the immune system. Our recent research inferred support for the microgenderome by showing sex differences in microbiota-symptom associations in a clinical sample of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). This addendum expands upon the sex-specific pattern of associations that were observed. Interpretations are hypothesised in relation to genera versus species-level analyses and D-lactate theory. Evidence of sex-differences invites future research to consider sex comparisons in microbial function even when microbial abundance is statistically similar. Pairing assessment of clinical symptoms with microbial culture, DNA sequencing and metabolomics methods will help advance our current understandings of the role of the microbiome in health and disease.
KEYWORDS:
D-lactate; chronic fatigue syndrome; clinical symptoms; microbiome; myalgic encephalopathy; neurological manifestations; sex differences
PMID: 27808584
DOI: 10.1080/19490976.2016.1256524
https://www.ncbi.nlm.nih.gov/pubmed/27808584
http://www.tandfonline.com/doi/full/10.1080/19490976.2016.1256524