Some good points definitely. I have balanced out at 2.5mg four times a day. I dont need to 'mimic' a cortisol curve as I dont have one, the idea is that I slowly add support to my body with the synthetic cortisol, im not trying to 'rest' my adrenals like STTM claim, just help my body find a natural balance knowing it has SOME of the hormones it needs rather than giving it 'all' and downgrading production. Ive been without for so long, my receptors are so sensitive anyway. My liver problems I think are the key to my issues - I have recently switched to Dr Wilsons Adrenal Rebuilder as I just cant tolerate the Miladregen - and Ive found vitamins are actually my problem. I dont have any issues with the rebuilder - so the clearance of the metabolites from the vitamins are the problem. However I dont tolerate any liver cleansing other than a dropper full of Milk Thistle liquid three times a day, anything above that is over stimulating and then crash. I am highly copper toxic - I tried copper detox without being stronger and it almost killed me! Lol, Pregnonelone - turns me batsh*t crazy of hyper up overemotional super anxiety weeping in my head but wanting to fight a war in my body - for me, Preg turns to adrenaline, not cortisol.