Supplements will probably never cure ME/CFS The reason why nutritional supplements are obtainable without prescription is the fact that they do not have any significant physiological effect on human body. I don't know how FDA decides what drug will be prescription only but I know that similar administration in my country, i.e., SUKL, decides by assessing of how significant physiological effect a drug has on the human body. If a drug significantly interferes with human physiology than it will probably be prescription only. If a drug has only small or no effect on human physiology than it will probably be over the counter. And since ME/CFS seems to be a particular case of marked physiological dysfunction probably only those drugs capable of marked interference with human physiology can cure it. But of course only "The He, who isn't there" is omniscient and I can be mistaken in that some unusual dosage of these supplements or some unusual combinations of these ones can indeed cure CFS. But if some "Universally Redemptive Protocol" of some "CFS specialist" consists only of supplements and if further "Extra Ecclesiam nulla salus" it is highly suspicious to me.