I hope this is not going to be a controversial thread and I apologize ahead of time if it upsets people, I really don't mean to you will see below what I'm trying to understand. With all the testimonials I constantly read on PR about supplement X completely improving symptom Y, or e.g. combination of supplement A,B,C totally improving symptom D, I tend to feel that gosh even though I have ICC/CCC ME/CFS that something is different with my disease than others? In the almost 2.5 years I've had this disease I've been taking all sorts of different supplements and combinations based on what research I read and testimonials here on PR, which I do appreciate so much because we are all helping each other with our experiences. But no supplement or herb, absolutely nothing has ever changed any symptoms of my disease, or if it does affect some symptom it takes so many months to years to do this that there is no way I could attest it had any causation. Are other people in the same boat as me? Another thing I wanted to mention is when I've connected the dots and tracked posts from the same PR users over the years saying X greatly improved Y, and then A greatly improved B, and then C greatly improved D you would think that with all those testimonials and improvements to different symptoms that they would be significantly better now, but then you read more recent posts by the same user and they are in terrible shape. What is the disconnect? Are supplements only working for a while and then nobody posts follow up negative testimonials? Or are people wrongly associating a supplement or combination of to symptom improvement when it really had nothing to do with it?