I reported a bad experience supplementing 5-MTHF and m-B12. I've tried to reintroduce 5-MTHF many times since with consistently negative results, even at less than 100mcg per day. Experiments with low-dose TMG have also been very unpleasant. As much as I try to convince myself that @Freddd is correct -- that this is something to power through -- I feel in my bones every time that I am heading away from health, not toward it. It's frustrating, because my lab work indicates a clear need for folate and methylation support generally. Homocysteine and SAH are high. SAM is low, as are almost all the forms of folate in the chain. Recently, after some time away from eggs due to a suspected allergy, I started eating three or four raw egg yolks per day. Of course, I can't know for sure what nutrients are actually in there, but these are high-quality eggs, and I would be surprised if they were lower in folate than the USDA database figure of approximately 25mcg per yolk. So I should be getting roughly 75 to 100mcg of folate -- and as I understand it, the folate in egg yolk is entirely in the form of 5-MTHF. Yet I don't respond negatively to the egg yolks as I do to 5-MTHF supplementation. Interesting, no?