New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
Discuss the article on the Forums.

Sun sensitivity = SOD deficiency?

Discussion in 'Hypersensitivity and Intolerance' started by Sherpa, May 3, 2015.

  1. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

    Messages:
    625
    Likes:
    778
    USA
    I am extremely sensitive to sun rays.

    UV rays wipe me out. I get PEM, feel drained.

    10 to 20 minutes of being in indirect or direct sunlight, even with a big hat + glasses + good sunscreen,... can wipe me out.

    My theory: poor status of some key antioxidant. I have read about Nickel Toxicity & SOD and I wonder if I don't have some kind of metal / DNA adduct or toxin that is blocking some critical part of my biochemistry that is needed to tolerate oxidation from sun?

    Supplemental antioxidants like SOD or astaxanthin help some, but all the supplements get expensive and complicated.

    Any ideas on what might cause my extreme sensitivity to sunlight?
     
    Last edited: May 4, 2015
    ebethc, merylg, rosie26 and 2 others like this.
  2. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,020
    I crash from UV light as well. I'm not sure of the exact cause, but know that it increases inflammation. For example, prostaglandins:

    http://www.ncbi.nlm.nih.gov/pubmed/8423392

    Sunlight also depletes folate.

    I'm thinking of trying vitamin A (retinol). High vitamin D levels with insufficient A is problematic. Sunlight gives me acne, and my skin is very dry. Retinol protects skin from photoaging, so perhaps it can counter some of the ROS from sunlight.

    Lutein might also work well, and vitamins C and E.
     
    Last edited: May 3, 2015
    merylg and Sherpa like this.
  3. ahmo

    ahmo Senior Member

    Messages:
    4,340
    Likes:
    6,528
    Northcoast NSW, Australia
    The onset of ME coincided with my absolute sun intolerance. It's one of the symptoms on the list for pyroluria. A week after I started pyroluria supps...P5P, zinc, mbdy, se...my reaction to sun ceased. Never returned. [​IMG]
     
  4. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

    Messages:
    625
    Likes:
    778
    USA
    Great! I need a miracle, too.

    This fits with my theory that I have a SOD deficiency. Supposedly Copper & Zinc & Maganese levels need to be semi-normal to produce enough SOD. Perhaps taking the zinc, molybdenum helped normalize your element levels?

    How much molybdenum did you take?
     
    merylg and L'engle like this.
  5. ahmo

    ahmo Senior Member

    Messages:
    4,340
    Likes:
    6,528
    Northcoast NSW, Australia
    yes, I always forget to include manganese. I can't remember how much mbdy I started with. I've varied at times, generally use self-testing. I'm currently taking high doses, as recommended by aaron_c, which is helping decrease my ammonia levels, 750mcg AM/PM. (Country Life 150mcg)

    Here's Klinghardt's protocol, which is where I began. Also, the pyroluria questionnaire.

    http://www.hputest.nl/evraag.htm Online questionnaire to suspect pyroluria
    http://www.lymeinducedautism.com/images/1_KlinghardtKPU_09_PX.pdf
     
    Last edited: May 3, 2015
    rosieness and ebethc like this.
  6. AndyPandy

    AndyPandy Making the most of it

    Messages:
    1,470
    Likes:
    6,614
    Australia
    Since ME/CFS I can't tolerate the sun. Causes significant increases in fatigue and pain.
     
    merylg likes this.
  7. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,020
    merylg likes this.
  8. douglasmich

    douglasmich

    Messages:
    311
    Likes:
    121
    Sherpa did you solve this? i have it too

    10min direct sun gives me severe brainfog and fatigue. takes 3-4 hours of lying down for it to wear off
     
  9. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

    Messages:
    625
    Likes:
    778
    USA
    Hi @douglasmich my sun sensitivity improved significantly as my thyroid function improved, on Dr. Brownstein's iodine protocol. As soon as I started taking iodine my fatigue-threshold and sun tolerance seemed to go up. I cannot prove that it was directly caused by that, but it seems correlated to me. I'm not sure it was SOD although supplementing it for a while could've helped some. I take it no longer
    just iodine, B12, folate.If you suspect subclinical low thyroid function might be a problem, I suggest the iodine test in my signature.
     
  10. Crux

    Crux Senior Member

    Messages:
    1,101
    Likes:
    768
    USA
    Another thing sun exposure does is to release nitric oxide from nitrites stored in the skin.

    Nitric oxide can be beneficial to healthy people, but if someone is producing a lot of it to fight infections,etc., then increasing NO can cause pain, inflammation, so on.

    This article is about the potential benefits of sun exposure and NO production :

    http://www.medicalnewstoday.com/articles/260247.php
     
    rosie26, Gondwanaland and adreno like this.
  11. Viking

    Viking

    Messages:
    67
    Likes:
    26
    Might want to assess omega 3 status as well. Skin needs proper fats for normal tolerance to sunlight.
     
  12. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

    Messages:
    625
    Likes:
    778
    USA
    @douglasmich

    No I didn't solve it. It simply went away for the winter, when the UV rays in my tropical area are less intense. Now that the summer sun is coming back... I am back to crashing after 15 - 20 mins at the beach, with severe brain fog and fatigue, where it takes 3 - 6 hours of lying down for it to wear off. Like you!

    I read this link about the Marshall Protocol & Photosensitivity with much fascination. It says:

    In individuals with chronic inflammatory diseases, 1,25-D is rapidly synthesized from 7-dehydrocholesterol when sunlight falls on the keratinocytes of the skin. According to the Marshall Pathogenesis, many of the keratinocytes of Th1 patients are parasitized by bacteria, they produce interferon-gamma (which is part of the bacterial defense mechanism) and TNF-alpha. These cytokines cause the cells of patients to produce much more 1,25-D in their skin than their healthy counterparts. Studies show that all 25-D produced in the skin of individuals with Th1 disease from sunlight is hydroxylated directly into 1,25-D, leaving no 25-D to be stored in fatty tissues. In healthy people, however, there will be remnant 25-D generated. Photosensitivity does not seem to be correlated with a patient's level of 25-D.


    Then I read posts on PR and on Mercola saying that the Marshall Protocol is not recommended, that it's potentially dangerous and "crackpot."

    I am still toying with the idea that the sun produces free radicals and my antioxidant status is poor. I am going to trial MitoQ which is said to be a possible fix for my SOD2 A16V +/+ mutation and see if I do any better. One review of MitoQ on amazon a woman says it helped her "heat tolerance"
     
  13. douglasmich

    douglasmich

    Messages:
    311
    Likes:
    121
    My d3 was over range. 190 (range 40-140)

    That was in september so i quit my d3. Started up d3 again at 5000iu
     
  14. hamsterman

    hamsterman

    Messages:
    88
    Likes:
    120
    Los Angeles
    Wow... its amazing how standard this is. 15 minutes of sun = 3 - 6 hours of PEM. I'm the exact same way... dealing with it now.

    Its not just sun, its heat. I got too much heat today from my car's AC not working. I started feeling horrible... and I noticed my Heart Rate went up to 100... is normally around 80 in the car.
     
  15. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

    Messages:
    625
    Likes:
    778
    USA
    According to Jack Kruse : "NADH is tied to UV light assimilation in all living things. Through these coupled processes, the reduced NADH is oxidized back to NAD+. In all human disease and aging NAD+ drops."

    I have been taking Niagen (250mg on awakening, 250mg at ~2pm) to raise my NAD+ levels and I find that I "Crash" less from sun exposure. This has allowed me to gradually build up my sun tolerance from 5 mins.. increasing by 1 minute per week (using a stopwatch) and now I have a tan and I am not as terrified of the sun as I used to be. I can't deal with extreme levels like hours on a summer beach at the hottest part of the day... , but normal amounts like shopping, walking or light sunbathing don't bother me anymore.
     
    Last edited: Jul 19, 2016
    anne_likes_red likes this.
  16. caledonia

    caledonia

    Messages:
    4,203
    Likes:
    3,223
    Cincinnati, OH, USA
    My guess would be somewhere between pyroluria and adrenal fatigue.

    Being in the sun is the same as being in a far infrared or infrared sauna. You may be sweating out electrolytes which you're already deficient in. You may also be moving out metals or other toxins.

    I have to be careful to avoid excessive sun, heat and humidity or I can faint. The minute I start sweating I can start to get into trouble.

    I have adrenal fatigue and show borderline on the pyroluria quiz. I also have SOD A16V +/+ and oxidative stress. My thyroid is back to normal.
     

See more popular forum discussions.

Share This Page