1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
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Institute of Medicine (IOM) Review of ME/CFS Clinical Definition: First Open Meeting
Gabby Klein provides a useful summary of what was a very important, and quite extensive, IOM open meeting. US Government representatives, patient organizations, advocates and individual patients all made formal presentations...
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  1. Bloopy Buddy

    Bloopy Buddy

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    I got some Quantofix sulfate test strips and after testing my urine sulphur seems low.
    How do I interpret that in the context of CBS/BMHT heterozygous?
    Is being low in urinary sulphur a good thing, meaning that my sulphur pathway is good?

    Wondering if I can move on to try methylation now.
  2. triffid113

    triffid113 Day of the Square Peg

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    I don't kow but logically I doubt it. All it means is you're not getting more than you can handle. It can potentially mean you are not getting enough sulfur. Now tell me if you make enough SAMe (there is a test for that somewhere) and then you'll know your sulfur pathway is good. Or you can guess if you know your homocysteine and carnitine levels (such aqs via www.lef.org).
  3. maryb

    maryb Senior Member

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    Bloopy Buddy
    I guess you are in the US? I am looking to buy some sulphur strips in the UK.
  4. Bloopy Buddy

    Bloopy Buddy

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    SAMe? Would I be checking blood levels? How does that correlate understanding my ability to detox sulphur?

    @maryb- yes I am in the US. I got the sulphur strips from amazon.com
  5. caledonia

    caledonia

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    Yes, I would go ahead and try to move onto methylation supps. Start very low with only a fraction of a full dose to test the waters. Increase gradually as tolerated.

    If you're getting a stress/anxiety response, you may have to go back and do CBS. The CBS issue may not crop up until you try to take methyl donors. I think that's what Triffid is saying too.
    Star-Anise likes this.
  6. Bloopy Buddy

    Bloopy Buddy

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    Thanks! What qualifies as a methyl donor?
  7. Bloopy Buddy

    Bloopy Buddy

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    Also, I assume I should be staying away from sulphured supps:
    NAC, Glutathione, MSM, ALA
  8. Star-Anise

    Star-Anise Senior Member

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    Bloopy Buddy
    Methyl donors are potentially any chemical substance that has a free methyl group that it can donate for methylation purposes. The major ones within our circles are: SAMe, methionine, methyl-B12, methyl-folate, coenzyme Q10, melatonin... those are the ones that come to mind.
    Here's a list that has some that I'm not familiar with:
    http://autoimmunethyroid.wordpress.com/2006/04/16/list-of-methyl-donors/

    Yes. From http://www.heartfixer.com/AMRI-Nutrigenomics.htm
    Appendix II: Foods High in Sulfur(but please review Sulfites and Chronic Disease, by Rick Williams (available at the office or you can go to www.readingtarget.com/nosulfites) ​
    Dietary Sulfur Issues
    Sulfur is necessary for many metabolic functions, but sulfur deficiency is rarely an issue, as most foods contain sulfur or sulfur containing compounds. Excess sulfur can be a problem for those with CBS, BHMT, and SUOX mutations – here one needs to avoid foods and supplements high in sulfur (sulfites and sulfates).
    Supplements High In Sulfur
    Taurine
    Cysteine
    Methionine
    Glutathione
    Glucosamine Sulfate
    Chondroitin Sulfate and MSM
    Epsom Salts
    Magnesium Sulfate Cream
    Canned meats, Aged game
    Homemade yeast breads
    DMSA and DMPS (Metal Chelators)
    Milk thistle, Beyond C, and Heparin

    Foods High In Sulfur
    Vegetables:



    Garlic, Onion Family
    Kale
    Collards
    Pickles
    Cabbage
    Brussel Sprouts
    Kohlrabi
    Broccoli
    Cauliflower
    Bok Choy
    Mizuna
    Broccoli Rabe
    Chinese Cabbage
    Napa Cabbage
    Turnip / Rutabaga
    Canola / Rape Seeds; Greens
    Mustard Seeds
    Tatsoi
    Radish
    Daikon
    Horseradish
    Japanese Horseradish
    Arugula
    Watercress
    Peas
    Spinach


    Fruits:



    Raspberry
    Cranberry
    Currents
    All Dried Fruit
    Others:



    Vinegar (especially if prepared from wine)

    Alcohol Beverages (especially wine; not vodka - beer is less of an issue, especially German beer)
    Soft Drinks
    Animal Products
    Dairy
    Eggs
    Brazil Nuts
    Peanuts
    Soy

    All packaged and commercially prepared foods contain food additives, many of which contain sulfur; often this is not on the label. Organic foods are preferable here. Do not begin taking horsetail grass, spirulina, dandelion leaf, or parsley, as they contain low levels of sulfur. If they are already part of your protocol, you may continue taking them. Eliminate them only if having trouble turning your strips pink. Recognize that methionine and SAMe do contain sulfur, as do the sulfur containing amino acids taurine and cysteine. After strict sulfur elimination for 3 to 4 months you will have eliminated the deep stores of sulfur in your body. Thereafter, you can begin adding very small amounts of sulfur and ammonia producing products back into your diet, while watching your strips to be sure they stay pink.
  9. caledonia

    caledonia

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    Actually the Free Thiol list works just as well and is less restrictive. Free thiols, not sulfur, per se, are the real issue. For example, I was taking large amounts of taurine and eating meat the whole time I was doing the CBS protocol and it still worked. See the link in my signature.

    TMG, which people take for the BHMT pathway is also a methyl donor. TMG = tri methyl glycine.
    Star-Anise likes this.
  10. Bloopy Buddy

    Bloopy Buddy

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    Thanks for all the replies!

    I am doing a metals challenge test today and took 2000mg DMSA.
    This is a high sulphur compound. If I have sulphur problems would I feel any negative effects from this?
    I don't seem to have any negative reaction going on.
  11. caledonia

    caledonia

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    I don't know what effects specifically you would get from the sulfur part, but when the metals come out, you may feel achy and tired.

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