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Sudden red face and arms - normal methylation symptoms?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by joe12, Oct 21, 2014.

  1. joe12

    joe12 Senior Member

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    Today I was making a phone call and had only a little bit of stress while asking some questions, and somehow this translated into a sudden reaction of very red and burning ears, red spots on my forehead, reddening of the face, as well as itchy red skin on the upper part of my hands and arms. I also felt a sudden stomach or intestinal discomfort. This lasted for about five minutes. Another symptom I noticed yesterday was a slight numbness of my head, specially to the back.

    I did take more L-Methylfolate a couple of minutes before this, from 400 to 800 mcg as it was suggested for a decrease in depression. The actual suggested amount was 10-15 mg per day thou.
     
  2. Martial

    Martial Senior Member

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    Sounds like flushing. Were you also using any form of niacin?
     
  3. joe12

    joe12 Senior Member

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    I am using niacin from B-Right, about 25 mg. It was definitely flushing.

    Worst case scenario is carcinoid syndrome, since I had some above average activity of some carcinogenic marker. I also had residue of the thymus and a lytic lesion on a rib, this was found three years ago. I have also had constant pain on my lower left pelvic area that radiates towards my left leg, but doctors have ignored this saying its most likely some gastrointestinal problem (you know how easily doctors can dismiss some of us). If it was cancer thou, I would probably be dying by now since this has been occurring for over three years now. But I still wonder what it is since it cannot be good and maybe could develop into a tumor.

    The other possibility is some kind of micro-circulatory problem, and maybe some evidence for this is how difficult it can be to take blood test sometimes, and having high blood pressure, and a small heart murmur. But if this was so, what could be the effect of methylation?

    I also now wonder what connection could there be between the thymus residue and lower NK cell activity. Perhaps the residue is an indication of lower effectiveness.
     
  4. Martial

    Martial Senior Member

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    Its just flushing I got the same exact thing from niacin a few times, thats extremely common. You should check and make sure if methyl folate and b12 would be good for you though, I heard they have tumor promoting properties if already present. I do not know a whole lot about all of that though. Just something to possibly look into.

    Lowered NK cell function is pretty indictive of things like HIV, and Chronic Lyme, among others. I am not sure how it presents with other causes of CFS. I have Lyme though and my NK cells were very low, better now with treatment though.

    edit* I re looked into it and it seems in some cases its actually anti tumor promoting, there is the possibility of tumors growing b12 and folate receptors as well but its really hard to say. I would think its probably over all safe enough and perhaps even good as preventive, just making sure not to over do it and looking into that could be important I guess.
     
    Last edited: Oct 21, 2014
  5. joe12

    joe12 Senior Member

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    It makes sense just because it would increase metabolism. I did not have a tumor when a pelvic ct scan was made thou.

    I do have a distended stomach, so maybe it could be stomach where somehow the pain extends much lower. I will be looking into it with a specialist thou.

    Other than that, the flushing is probably not a bad sign right?
     
  6. Martial

    Martial Senior Member

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    Or sciatica, there is a lot of possible reasons but I think a tumor causing it would be extremely low, the flushing is totally normal when people take niacin, its called a niacin flush after all lol.
     
  7. taniaaust1

    taniaaust1

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    It sounds like a niacin flush to me. In Naturopathy collage were taught people can often do that wen taking that B and that its a sign they are deficient so needing it. (Its one of the ways a deficiency can apparently be tested).
     
    zzz likes this.
  8. joe12

    joe12 Senior Member

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    Probably not sciatica because when I go to bed, if I sleep pressing on my right side (the side with no pain) my left hurts more, and if I sleep pressing on my left side the pain is reduced.
     
  9. joe12

    joe12 Senior Member

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    Makes sense, it seems niacin increases good cholesterol, for which I am low.
     
  10. Critterina

    Critterina Senior Member

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    Niacin is primarily a vasodilator, which causes the flush.
     
  11. joe12

    joe12 Senior Member

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    @Critterina @Martial @Hip
    I stopped methylation because even thou it seemed to do good, I would like to test homocysteine first, plus NK CD16 and CD56, CD8, CD4, EBV, and maybe a functional NK test (not sure the difference between CD56, CD16, and a functional test thou) after I recover from whatever virus I got, so I would want to avoid any potential alteration. I really hope it won't be a waste and that it will provide me with some important evidence. I am also thinking of getting the 23andme or a targeted test from GeneDx.

    After stopping for a few days I crashed, some of the symptoms likely from higher viral activity, and now have higher pain in my lower left abdominal area that is also producing a burning sensation in my left leg. It is somewhat worrying but maybe its not too bad and could provide important clues. The truth is that I have been getting this pain for a long time with varying degree. I am thinking about visiting a gastroenterologist next week.
     
  12. Martial

    Martial Senior Member

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    Methyl folate helps to lower homocystiene but having a 23andme test is definitely worth while. Hope you can figure out some more answers after you get the testing done!
     
  13. Critterina

    Critterina Senior Member

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    Sorry I don't have any advice to give you. I am encouraged by the fact that you didn't crash until you stopped methylation supplements. That might mean they are doing you good and you'll feel better once you restart; at least we can hope so. I don't know the difference between those cells, either, to be honest. Let us know what you find out.
     
  14. joe12

    joe12 Senior Member

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  15. taniaaust1

    taniaaust1

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  16. joe12

    joe12 Senior Member

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    Toll-like receptors, they are proteins on the surface and the inside of phagocytic cells like neutrophils and macrophages which detect viruses and bacteria and then when binding they react to destroy them. If there are mutations on them then they might not work and chronic infections might develop.
     
  17. Valentijn

    Valentijn WE ARE KINA

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    I have a rare homozygous mutation at rs9462852 (which is present in 0.07% of the general population) on CNPY3, a gene which regulates the cell surface expression of TLR4. No idea if that SNP has any impact. It looks like it isn't on an exon.
     
  18. joe12

    joe12 Senior Member

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    What lab test did you use?
     
  19. Valentijn

    Valentijn WE ARE KINA

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    23andMe
     
  20. joe12

    joe12 Senior Member

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    I have been considering getting the test done, but I don't think this is the best method to identify mutations regarding the different antigen recognition mechanisms even thou I haven't really figured what to do about the suspicion.

    So far I have read that the possibilities, regarding viruses, lie in TLR structure mutation, lack of interferon production, lack of response to interferon, dysfunction of the complement system, lack of replication of specific antigen receptors on B cells and T cells from poor recognition or poor formation, poor peptide presentation from the human leukocyte antigen complex from either poor formation of the heavy chain or from mutations in the b-microglobulin, and dysfunction of NK cell activity.

    I was hoping to deduce the problem from viral recognition from symptoms but this is proving very difficult. In my case it is affecting the tissues on my nasal mucus and eyes producing fairly constant pain, and it might also be affecting the CNS. This might also be due to autoimmune process due to dysfunction of the HLA/MHC. Poor blood flow could also be a factor.
     

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