I have two working copies of the ALDH2 gene (rs671 G;G) and have never experienced any kind of alcohol flush. For two weeks I tried pycnogenol (pine bark extract) and ended up with a severe acne breakout the likes of which I've never seen since I was a teenager. I've been off it for a week and my skin is completely clear again. This past week, to combat a potential respiratory infection I felt coming on from being around a lot of sick coughing people, I took 250mg of Grapefruit Seed Extra 3 times per day all week. Luckily the cough went away quickly. However, I now seem to be completely intolerant of alcohol. Even half a glass of wine or a single 4.5% ABV ginger beer will give me a severe alcoholic facial flush and I can feel the blood throbbing in my veins across my entire body. Could the pycnogenol or Grapefruit Seed Extract have somehow disrupted my liver's ability to process acetaldehyde efficiently? Or is this a potential sign of something else going on with my body?