Hi all. So have to be careful with the way things are worded because apparently can't give medical advice here. In the dropbox link is a lot of studies on succinic acid https://www.dropbox.com/sh/kq2p8rwpyu3xu0p/AABtBrxSKbZu3nNVZAns8wYxa?dl=0 There is study showing 6g a day treats MELAS syndrome- a severe mitochdondrial disease caused by a mutation in the electron transport chain. There is another study saying succinic acid can treat all electron transport chain diseases. Because of its role in the electron transport chain it could treat any blockage anywhere in krebs cycle or the pyruvate dehydrogenase complex. Medical geneticists, pharmacists, and other experts in the field know about it but keep it secret so they can exploit sick people for money. Unpleasant but oh well don't dwell on it. I am on succinic acid for 3 days now, 20g first day, 15g second day, and only about 3g today, and will continue taking it as I suspect I have an undiagnosed mitochondrial disease. I will find a standard dose, and settle on it, maybe around 5-6 g a day. I will update when I get better on it. The amino acid threonine has been studied for PKU (it lowers phenylalanine), and MS (loosens muscles/stops spasticity). Studies on that are in the file too. This was copy pasted from a website in Russian, as they have more info on succinic acid in their country than in English countries. The website is in the public domain. http://www.prosto-mariya.ru/yantarnaya_kislota_svoistva_i_primenenie_220.html (more in the succinic acid info text file- not allowed to post too much text).