I had severe Adrenal Fatigue Syndrome which I recovered from after 2 years of intensive supplement protocols, diet and yoga... but was left with a case of mild CFS. I was able to work (most of the time) but socializing was extremely difficult (half the time I would cancel, or I couldn't stay out past 9pm), exercise was challenging, and my overall quality of life with no friends and low energy was very low. I was depressed and often miserable. I spent a year in this state and made little or no progress. I came to this forum and learned about B12. I learned about Dr. Teitelbaum's "Energy Revitalization System" vitamin drink formulated for fatigue which had 500mcg of cyanocobalmin. I tried it and it seemed to work right away. But I still "ran out of steam" -- or ATP -- about 3 or 4 pm every day. I added d-ribose. I had tried it before intermittently and my body had different reactions ranging from wired to effective. I would also feel the energy drop off sharply after the ribose wore off, approximately 6 hours after dosing. It felt depressing. I started at 750mg dibose twice a day and fairly quickly worked up to 5 gram doses. 9am and 3pm... which gave me energy from 6am to 9pm. It felt good. My body was healed enough to handle the extra energy, my blood sugar was stable, etc. After about 1 month of being on 5 grams of r-ribose twice a day, I feel MUCH better. I feel like I did long before I started to descend into the abyss of chronic illness. I think my body has "Adjusted" to the ribose supplementation and it expects it, knows how to handle the energy, and doesn't get much .. if any... agitation or insomnia anymore. I've been feeling anywhere from "good" to "awesome" most of the time - a big contrast to the past several years My daily supplement mix is: 1 scoop Energy Revitalization System 1500mg powdered vitamin C 300mg (half capsule) of NAC - N-acetyl-cystine 5g of d-ribose 2x daily (9am and 3pm) Standard process Thyrotrophin PMG 3x a day 400mg magnesium (mixed types) I know that I am "lucky" to get good results with such a simple regime but I did 2 years of round-the-clock efforts treating my adrenals, thyroid and diet before I got the the point where this could work. Hope this effects continue and may all attain! Jah bless.