First post to this forum/blog; been lurking for about six months. Learned a lot about treating myself with measurable success but I’ve recently had a setback after titrating sublingual Methyl B-12 and Adeno B-12 concurrently while taking a low dose of L5MTHF. (Nonetheless, I’ve been able to help my daughter who has been mostly bedridden for 8 years with ME/CFS). Thanks to all contributors! Briefly my story: Diagnosed 8 years ago w/B-12 insufficiency treated with 1,000 mcg of Cyano B-12. Starting in the ‘70’s, decades of absent ankle/knee jerks. Gradually developed numbness in feet and legs. EMG/NCVs showed substantial signal latency and conduction block. Had chronic connective tissue problems (tendon tears, pain), sinus infections. Got diagnosis of Distal Axonopathy (sensorimotor, stocking-glove distribution, symmetric, progressive, not immune-mediated). I do not know if I have ME/CFS. I do know some of this site’s protocols have helped me. Over the years, Vet Affairs and three outside neurologists agreed on DA diagnosis, but not the etiology: Vet Affairs: toxin exposure (Agent Orange) Other Neuro #1: don't know but probably diabetes (I.e., subclinical) Other Neuro #2: looks a lot like diabetes Other Neuro #3: don’t know but you do NOT have diabetes I got really tired of going to Neuros, just to have them measure my deterioration so I began to do some research. I found this site and, making a long story short, I stopped taking Cyano B-12 and started taking (5,000 mcg Kirkland) MB-12. The NEXT MORNING my calves weren’t painful, walking was more “solid”, and things continued to improve. Five months later I had regained much balance, legs were only minimally numb, pudendal nerve recovered, regained hand/finger articulation, mind more clear, lipids 25% better, anxiety way down, numerous psych meds no longer needed, connective tissue pain largely gone, more energy, markedly reduced hand tremor, and more. Several times over the past months I have tried to add AB-12 but felt bad and had to stop. Was able to titrate MB-12 to 15,000 mcg. Things were going well. Progressive nature of numbness in feet, legs and hands stopped; motor deficits substantially improved. Three weeks ago I began adding AB-12 and upping MB-12. I reached 50,000 mcg MB-12 and 15,000 mcg AB-12, and continuing with my standard 200mcg L5MTHF. I increased MB-12 in hopes of getting a greater effect in my mostly numb feet. However, I noticed the numbness in my feet was slowly increasing and is now advancing so quickly that I can tell the difference each morning as I wake up. Also, aches and pains that were common before I started methylation that taking MB-12 eliminated, have returned. When the result of my supplements regimen goes south, I return to baseline, so a week ago I went back to 5,000 mcg of MB-12, no AB-12, no L5MTHF. Titrated MB-12 to 20,000 mcg, eventually L5MTHF to 200 mcg. I read more on Paradoxical Folate Deficiency and 2 days ago went to 400 mcg with L5MTHF, then 800 mcg today. I feel better but the numbness still appears to be progressing, now with renewed Pudendal nerve involvement. Question: Does this scenario look like paradoxical folate deficiency? Freddd, is this somewhat similar to the neurological problems you are dealing with?