Hi SD funny you mention electron transport chains, because these are closely related to the ion channels that Mike said are so critical to fix. I really think those chains are the key to restoring mitochondrial dysfunction. Myhill says the blocking of these chins (I-V) in the inner mitochondrial membrane is due to toxic stress. However, most suggestions are dietary and meant to control damage vs. fix the issue. If neural therapy could restore these chains and ion channels, that would mean cells could start functioning again and theoretically allow oxidative phosphlorylation to work again.