I experienced generalized fat loss very recently. About 9 years ago I was diagnosed with CFS. After a few years it got better, although I never fully recovered. February-March this year everything got worse. A few weeks after a streptococcus infection which was treated with antibiotics for 10 days, I suddenly got joint pains and cracking and severe subcutaneous fat loss throughout my entire body, from face to feet soles. I lost 10 pounds in weight, but put them back on. The fat loss however stayed. There seems to be a fat redistribution as well (more fat in breasts and abdomen which I really notice since I am very slim). The doctor only found elevated ASO titers at 800, some vitamin D deficiency but not too bad, slightly elevated uric acid and rather high glucose level (this might be connected to the fat loss, I never got that problem before; suddenly I am in a pre-diabetic state). No sign of any auto immune diseases, lyme infection,.... I am very concerned by this, my appearance is changing completely and my joints continue cracking. The only thing we can think of now is Lawrence-Seip syndrome, a rare condition of acquired generalized lipodystrophy.