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Stunning Diversity of NK Cell Receptors found

Discussion in 'Other Health News and Research' started by Sparrowhawk, Oct 31, 2013.

  1. Sparrowhawk

    Sparrowhawk Senior Member

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    Saw this on my FB feed this morning. On rereading I see my title should probably have been Stunning Diversity in NK cell RECEPTORS found, apologies:

    http://www.niaid.nih.gov/topics/immuneSystem/Pages/naturalKillerCells.aspx



    So I wasn't sure where they were going with this but it appears the main finding is there are not, as I had assumed, just one kind of NK cell. There are two main kinds, and amongst those there are a HUGE range of variations.

    My bolds, above and below.
    Holy NK cells batman, that potentially makes NK cell involvement in CFS/ME that much more complicated...or may simplify things if we learn only certain types of NK cells are involved.
     
    leela, heapsreal, snowathlete and 2 others like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Other cfs studies mention dim and bright nk cellsand its the nk bright cell ffunction thats commonly low. So maybe those who test normal nk function possibly have a low bright cell function they dont know about. This type of testing though is only a research test.
     
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  3. snowathlete

    snowathlete

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    Could become an important finding. Thanks for posting.
     
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  4. anciendaze

    anciendaze Senior Member

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    Don't assume the expression of receptors is static. There is a great deal of modulation, both internal and external. The chief cell types to consider are NK , NK/T cells and dendritic cells. There is a great deal of communication between them.

    Not only do NK cells play a vital role in innate immunity, they are also one key to the interface between innate and acquired immunity. In health, they generally avoid lymphoid tissue, but concentrate there in infection. Besides attacking infected cells, they will even destroy uninfected dendritic cells which seem to be promoting an undesirable response. This makes them very important in autoimmune disorders.

    If all that were not enough, they play important roles in natural development, where destroying unwanted cells is as important as growing those desired. I suspect they are important in autism, due to the peculiar nature of human neurological development, which continues long after birth.

    Humans are born in an unusually helpless state. Quite a number of mammals, e.g. pronghorns, are born with the ability to stand, walk and run within minutes after birth. Even marsupials are able to crawl to the pouch and find a nipple without a great deal of help. Human babies not only have trouble controlling their neck and limbs at birth, they also lack control of their eyes. (Part of the appeal of puppies or kittens may be the way they resemble our own young in this respect.) Problems with passage through the birth canal limit the amount of brain development which can take place prior to birth, even if there were no problem in getting useful environmental stimuli. This means a great deal of brain development must take place after the neonate has left an immunologically-privileged environment. This is precisely the point at which autism becomes manifest.
     
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