Study links PI3Kgamma molecule with MS

[GhostGum]

Thought the stuff about the molecule being involved in inflammatory conditions and autoimmune encephalitis was interesting.

I wonder what drug they used to block the activity of the molecule? Will try and check later, dinner time

http://www.news-medical.net/news/20...3Kgamma-molecule-with-multiple-sclerosis.aspx

"There's already been worldwide interest in PI3Kgamma in relation to other human inflammatory disorders, such as diabetes and rheumatoid arthritis, and our study links this molecule and MS," said Dr Comerford, who is a Multiple Sclerosis Research Australia Fellow at the University of Adelaide.

Dr Comerford and his colleagues have now shown that this molecule is crucial for the development of experimental autoimmune encephalitis (EAE) in an animal model developed as a standard laboratory system for studying MS.
The team showed that a genetic alteration, which knocked out that particular molecule, resulted in a high resistance to the development of EAE and therefore protected against the nervous system damage typical of multiple sclerosis.
When the molecule is present, severe damage to the insulating myelin in the central nervous system was evident, resulting in inflammation in the spinal cord and myelin loss.
Following up on this result, the team then used an orally active drug that blocks the activity of the molecule PI3Kgamma at the first signs of disease onset. The drug even suppressed the development of EAE and reversed clinical signs of the disease.

 

[Enid]

Interesting GhostGum - I had two Neurologists speculating in my early days of myelin sheath damage. (All the symptoms/evidence to them though MS ruled out).

 

[GhostGum]

Interesting GhostGum - I had two Neurologists speculating in my early days of myelin sheath damage. (All the symptoms/evidence to them though MS ruled out).

Hey Enid, reading that about the myelin damage and loss, inflammation in the spinal cord it all sounded like hallmark ME to me and why I had to post it; the myelin sheath must play a part in brain inflammation in ME, whether the myelin is actually damaged I have no idea?

Would be really interesting to find out what drug they used and how much success they are having with it, could be a serious option in treating ME inflammation.

 

[Enid]

Hi GostGum - very much related I think too. My MRI brain scan showed patches of "high signal changes" and abnormal brain scans are now very central in ME diagnostics (pathology findings). The drug does sound interesting for repair in the nervous system. What caught my eye too was "the reduction of movement by immune cells into the central nervous system" - I'm no biologist but do wonder how the problem is set up - eg infections.

 

[GcMAF Australia]

yes i played volleyball with his colleague Shaun McColl< well actually used a ball. and went out with Shaun's sister Kim McColl.

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045095
pdf is available by ticking the pdf link
"Therefore, while PI3Kγ has been shown to make an important contribution in several models of human inflammatory disease including RA [17], [18], SLE [19], diabetes [20], asthma [21], [22] and now MS, whether or not this enzyme will make a safe and effective drug target in these human diseases should now be determined."
Many people accept this inflammation is "cause" of disease. and they are using treatments to cure and prevent the disease.
It is about time the grant bodies got on board.

 

[aprilk1869]

At the moment I'm trying to read up on lipopolysaccharide (LPS) produced by bacteria. So I did a quick search for LPS + PI3Kgamma and came across this...

"We conclude that PI3Kgamma is required for transepithelial but not for transendothelial migration in LPS-induced lung injury. Inhibition of PI3Kgamma activity may be effective at curbing excessive PMN infiltration in lung injury."
http://www.ncbi.nlm.nih.gov/pubmed/19797129

 

[heapsreal]

interesting how they put rhuematoid arthritis and MS in the same category. The bond uni guys studying nk bright cell function in cfs/me were looking into doing a similar study comparing rheumatoid, MS, CFS/ME with healthy control group to help with a diagnostic test for cfs/me. They also seemed to hint at cfs/me being an auto immune illness a few years ago when they commenced their study. So maybe they think treatments used for rheumatoid and MS could be helpful for us??

 

[GhostGum]

Oh boy I am so tired I do not know where to start with this, no science for my brain today, does anyone know how to host pdf files for everyone to view or how to add them here? I actually wrote to Iain about his research, about ME/CFS (which he had no real idea about) and he sent me back four pdf files regarding his research, two are research papers I think and two are reviews.

He also said the drug they used is called AS605240 which is the PI3K inhibitor.

I am hoping I can get him and Dr Sonya Marshall talking since their work seems to have some pretty obvious similarities, they are basically both looking at neuroimmunopathology, one in MS and the other in ME.

 

[GcMAF Australia]

Example of drugs that help more than one disease
Metformin - diabetes & cancer, (and polycystic ovary syndrome): from goat's rue (Galega officinalis)

 

[GhostGum]

Ok hopefully this works,

Reviews (easier on the brain),

http://www.filedropper.com/review

http://www.filedropper.com/review2

Papers,

http://www.filedropper.com/journalofautoimmunitypaper

http://www.filedropper.com/plosonepaper

I guess at the end of the day we just have to wait and see how the research pans out and whether it becomes viable for combating inflammation or not. Just hope I have done something in making Iain aware of ME and also Sonya's similar research; I tried to find an email to contact her as well to also make her aware of this work but no luck, I am sure she will hear about it sooner or later though or Iain will even contact her.

Where did that 'upload a file' option come from? I swear it was not there last night