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Study links PI3Kgamma molecule with MS

Discussion in 'Other Health News and Research' started by GhostGum, Oct 6, 2012.

  1. GhostGum

    GhostGum Senior Member

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    Thought the stuff about the molecule being involved in inflammatory conditions and autoimmune encephalitis was interesting.

    I wonder what drug they used to block the activity of the molecule? Will try and check later, dinner time :)

    http://www.news-medical.net/news/20...3Kgamma-molecule-with-multiple-sclerosis.aspx

     
    justy, merylg and Enid like this.
  2. Enid

    Enid Senior Member

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    Interesting GhostGum - I had two Neurologists speculating in my early days of myelin sheath damage. (All the symptoms/evidence to them though MS ruled out).
     
  3. GhostGum

    GhostGum Senior Member

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    Hey Enid, reading that about the myelin damage and loss, inflammation in the spinal cord it all sounded like hallmark ME to me and why I had to post it; the myelin sheath must play a part in brain inflammation in ME, whether the myelin is actually damaged I have no idea?

    Would be really interesting to find out what drug they used and how much success they are having with it, could be a serious option in treating ME inflammation.
     
    Enid likes this.
  4. Enid

    Enid Senior Member

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    Hi GostGum - very much related I think too. My MRI brain scan showed patches of "high signal changes" and abnormal brain scans are now very central in ME diagnostics (pathology findings). The drug does sound interesting for repair in the nervous system. What caught my eye too was "the reduction of movement by immune cells into the central nervous system" - I'm no biologist but do wonder how the problem is set up - eg infections.
     
  5. GcMAF Australia

    GcMAF Australia Senior Member

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    yes i played volleyball with his colleague Shaun McColl< well actually used a ball. ;) and went out with Shaun's sister Kim McColl.

    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045095
    pdf is available by ticking the pdf link
    "Therefore, while PI3Kγ has been shown to make an important contribution in several models of human inflammatory disease including RA [17], [18], SLE [19], diabetes [20], asthma [21], [22] and now MS, whether or not this enzyme will make a safe and effective drug target in these human diseases should now be determined."
    Many people accept this inflammation is "cause" of disease. and they are using treatments to cure and prevent the disease.
    It is about time the grant bodies got on board.
     
    merylg likes this.
  6. aprilk1869

    aprilk1869 Senior Member

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    At the moment I'm trying to read up on lipopolysaccharide (LPS) produced by bacteria. So I did a quick search for LPS + PI3Kgamma and came across this...

    "We conclude that PI3Kgamma is required for transepithelial but not for transendothelial migration in LPS-induced lung injury. Inhibition of PI3Kgamma activity may be effective at curbing excessive PMN infiltration in lung injury."
    http://www.ncbi.nlm.nih.gov/pubmed/19797129
     
    merylg likes this.
  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    interesting how they put rhuematoid arthritis and MS in the same category. The bond uni guys studying nk bright cell function in cfs/me were looking into doing a similar study comparing rheumatoid, MS, CFS/ME with healthy control group to help with a diagnostic test for cfs/me. They also seemed to hint at cfs/me being an auto immune illness a few years ago when they commenced their study. So maybe they think treatments used for rheumatoid and MS could be helpful for us??
     
    merylg likes this.
  8. GhostGum

    GhostGum Senior Member

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    Oh boy I am so tired I do not know where to start with this, no science for my brain today, does anyone know how to host pdf files for everyone to view or how to add them here? I actually wrote to Iain about his research, about ME/CFS (which he had no real idea about) and he sent me back four pdf files regarding his research, two are research papers I think and two are reviews.

    He also said the drug they used is called AS605240 which is the PI3K inhibitor.

    I am hoping I can get him and Dr Sonya Marshall talking since their work seems to have some pretty obvious similarities, they are basically both looking at neuroimmunopathology, one in MS and the other in ME.
     
    heapsreal, merylg and justy like this.
  9. GcMAF Australia

    GcMAF Australia Senior Member

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    Example of drugs that help more than one disease
    Metformin - diabetes & cancer, (and polycystic ovary syndrome): from goat's rue (Galega officinalis)
     
    heapsreal likes this.
  10. GhostGum

    GhostGum Senior Member

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    Ok hopefully this works,

    Reviews (easier on the brain),

    http://www.filedropper.com/review

    http://www.filedropper.com/review2

    Papers,

    http://www.filedropper.com/journalofautoimmunitypaper

    http://www.filedropper.com/plosonepaper

    I guess at the end of the day we just have to wait and see how the research pans out and whether it becomes viable for combating inflammation or not. Just hope I have done something in making Iain aware of ME and also Sonya's similar research; I tried to find an email to contact her as well to also make her aware of this work but no luck, I am sure she will hear about it sooner or later though or Iain will even contact her.

    Where did that 'upload a file' option come from? I swear it was not there last night :D
     

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