The study was discussed recently in an article on Phys.org titled "Do our mitochondia run at 50 degrees C?" https://phys.org/news/2018-01-mitochondria-degrees.amp "The authors' results appear to show that, in maintaining our body at a constant temperature of 37.5°C, mitochondria operate much like thermostatic radiators in a poorly insulated room, running at a much higher temperature than their surroundings." .... "Specifically, the probe's fluorescence suggested that the temperature of the mitochondria in living and intact cells, themselves placed in a culture medium maintained at 38°C, is more than 10°C higher, as long as the mitochondria are functional. This elevated temperature is abolished when the mitochondria are inactivated by various means." For those of us whose chronic fatigue is due to mitochondrial disease or dysfunction, I wonder if this explains the cold feet, normal lower body temperature, and the change in weather temperature related uptick in symptoms?