The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

Studies find HHV-7 active in ME, yet ME Drs often don't test for it & Valcyte doesn't work for HHV-7

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Hip, Feb 21, 2018.

  1. Hip

    Hip Senior Member

    Messages:
    10,695
    Likes:
    17,596
    Yes I saw it, but for reasons explained in this above post, antibody testing may be better. PCR often misses active infections in ME/CFS patients.
     
    BadBadBear likes this.
  2. Ema

    Ema Senior Member

    Messages:
    4,622
    Likes:
    6,669
    Midwest USA
    Yes, IV, maybe just shy of a full year, as a patient of Dr Lerner’s. I think I did 20 something, one every two weeks.
     
  3. ukrmen

    ukrmen

    Messages:
    16
    Likes:
    16
    Hip, thenk you for your attention to the problem identified in the title.

    I want to draw your attention to the fact that there is one more possibility to reveal high activity of HHV7. Despite the fact that the main reservoir of the persistence of HHV7 is lymphocytes with a CD4 marker, the place of its replication over the visible, like for HHV4, is the salivary glands. Despite the fact that in the vast majority of people the analysis of the PCR of saliva on HHV7 gives a positive result, a load of more than 500,000 copies in mL of saliva is likely to indicate an active process, while an IgG level in the plasma or cerebral is likely to give a dubious result . Do you have any opinion or information on this matter?

    I would also like to ask you why the fact that HHV7 does not destroy lymphocytes with a CD4 marker, in contrast to HIV, is explained.

    A commercial analysis of IgG and IgM plasma levels for HHV7 is available to a wide range of patients, for example, at the MDI Laboratorien (Medizinisch-Diagnostische Institute) in Germany.
     
    Last edited: Feb 28, 2018
    Countrygirl likes this.
  4. Hip

    Hip Senior Member

    Messages:
    10,695
    Likes:
    17,596
    That's interesting. Is an HHV-7 salvia test commercially available, do you know?



    It's usually experienced ME/CFS specialist doctors who will know the right tests for a given virus in ME/CFS. Antibody tests are the ones usually used by ME/CFS doctors, because antibody tests can detect chronic intracellular infections hidden in the tissues. In the case of enterovirus ME/CFS, we know that there is a chronic intracellular tissue infection in ME/CFS patients.



    I cannot find the HHV-7 test on their website.



    I don't know much about how HIV destroys CD4 T-cells, but it may relate to the fact that HHV-7 is often in a state of latency in CD4 cells, whereas HIV is constantly active in CD4 cells (HIV actually exists as an abortive infection in CD4 cell, and abortive infections are constantly active, but produce no new viral particles).
     
    Last edited: Feb 25, 2018
    bobbyD likes this.
  5. ukrmen

    ukrmen

    Messages:
    16
    Likes:
    16
    Hi, Hip.
    Here is the direct link http://www.mdi-labor.de/en/service-directory/?tx_laboratoryeditor_pi1[s_uid]=2986 for IgG and IgM antibodies analyzes for HHV7 by blood. The result is the measured antibody titers.
    The PCR test for saliva for the presence of HHV7 is technologically even easier than for whole blood and is, no doubt, available on the same test systems as for blood.
    If there is a practical interest, I can contact you by e-mail.
     
    frederic83, bobbyD and Hip like this.
  6. bobbyD

    bobbyD

    Messages:
    25
    Likes:
    3
    Hip,

    You are the best, thanks So much for all of your research, insight and objectivity. Recently my CFS flared up due throat infection and flu-like symptoms. it seems everyone in LA is getting this flu. Now I have a dry cough, and my throat feels like it closing, then I get some anxiety. I tried your anxiety suggestions, but this dry cough and swallowing issues still is creating problems.
     

See more popular forum discussions.

Share This Page