Started valtrex two days ago 1.5 g x 3 daily, rxed by Dr. Lapp. Now have enhaced fatigue, agitation, depression, flu feeling--really laying me down. No gi problems. Although i did have off the chart igg titres for ebv I wasn't expecting anything from this drug, esp within day or two. I also have lyme and this resonse is very similar to the lyme herx fom antibiotics, but is this fast and strong response normal for valtrex? I know Lerner and Montoya describe herx type reactions but concerned this fast of a response may be drug reaction. Appreciate comments from anyone having experiences with this? Dr. Lapp did say my titres were quite high, even for his patients, even though i rarely have swollen glands, fever, or typical acute ebv symptoms.